1069 Results for: "Tonbo Biosciences"

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, HRP Conjugate, min x w/ bovine, human, or mouse IgG or serum proteins

Supplier: Tonbo Biosciences

Donkey anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum

Supplier: Tonbo Biosciences

Goat anti-Mouse IgM (mu chain) - Affinity Pure, Biotin Conjugate

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - Affinity Pure

Supplier: Tonbo Biosciences

Donkey anti-Sheep IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate, min x w/human IgG or serum proteins

Supplier: Tonbo Biosciences

Rabbit anti-Human IgM (mu chain) - Affinity Pure

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate, min x w/human IgG or serum proteins

Supplier: Tonbo Biosciences

The 30-F11 antibody reacts with mouse CD45, which is one of the most abundant hematopoietic markers and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others. The 30-F11 antibody is widely used as a leukocyte marker for B cells, T cell subsets and NK cell subsets.

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - F(ab')2 fragment, Biotin Conjugate, min x w/bovine, goat, human, rabbit, or rat IgG

Supplier: Tonbo Biosciences

Goat anti-Human IgE (epsilon chain) - Affinity Pure, Biotin Conjugate

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L), F(ab')2 Fragment - Affinity Pure, Biotin Conjugate, min x w/human IgG or serum proteins

Supplier: Tonbo Biosciences

Goat anti-mouse IgG (H&L), F(ab')2 fragment, HRP conjugate, min x w/bovine, horse, human, pig or rabbit serum protein

Supplier: Tonbo Biosciences

Goat anti-Human IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

The M1/69 antibody reacts with mouse CD24, a cell surface molecule also known as Heat Stable Antigen (HSA). CD24 is a GPI-linked glycoprotein involved in cell adhesion and is a ligand for CD62P (P-selectin). It is expressed on erthrocytes, thymocytes, peripheral lymphocytes and myeloid lineage cells. The expression of CD24 is used to delineate stages of of lymphocyte development in the bone marrow.

Supplier: Tonbo Biosciences

The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Supplier: Tonbo Biosciences

The SK7 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The SK7 antibody is a widely used phenotypic marker for human T cells. This antibody may induce T cell activation in the presence of monocytes. The antibody has also been demonstrated to be cross-reactive with Chimpanzee CD3. Binding of clone SK7 can be blocked by an alternative Anti-Human CD3 clone, OKT3. Please choose the appropriate format for each application.

Supplier: Tonbo Biosciences

The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others. The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.

Supplier: Tonbo Biosciences

The 53-7.3 monoclonal antibody is specific for mouse CD5, a 67 kDa protein that is expressed on most thymocytes, mature T cells and the B-1 subset of B cells. CD5 is a member of the scavenger receptor cysteine-rich protein superfamily and is a ligand for the c-type lectin CD72. CD5 is also known as Leu-1 and functions to modulate antigen receptor signaling on T and B cells.

Supplier: Tonbo Biosciences

Ghost Dye™ Violet 450 is an amine reactive viability dye that can be used to discriminate viable from non-viable mammalian cells in flow cytometry applications.

Supplier: Tonbo Biosciences

7-AAD (7-Aminoactinomycin D) is a nucleic acid dye that can be used to exclude nonviable cells from the analysis of flow cytometry data based on light scatter and fluorescence properties.

Supplier: Tonbo Biosciences

Anti-PTPRC Rat Antibody (APC (Allophycocyanin)-Cy7®) [clone: LTF-2]

Supplier: Tonbo Biosciences

The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

Supplier: Tonbo Biosciences

The 2A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2a antibodies.

Supplier: Tonbo Biosciences

Tonbo Biosciences Foxp3 / Transcription Factor Staining Buffer Kit contains specially formulated buffers and solutions for optimal resolution and low background in your analysis of nuclear antigens by flow cytometry

Supplier: Tonbo Biosciences

The JES5-2A5 antibody is specific for mouse IL-10. IL-10 has numerous biological activities including the ability to inhibit both the synthesis of Th1 cytokines and proliferation of T cells. In the mouse, IL-10 is produced by phagocytic cells, conventional dendritic, cells, T cells, B cells, and NK cells. The JES5-2A5 antibody is a neutralizing antibody.

Supplier: Tonbo Biosciences

The OKT3 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Supplier: Tonbo Biosciences

The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.

Supplier: Tonbo Biosciences

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.