2458 Results for: "Stemcell Technologies"

Supplier: STEMCELL Technologies

Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello et al.). BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson et al.). It is expressed in the hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle et al.). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, and contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman).

Supplier: STEMCELL Technologies

Immunodensity depletion of CD4+ cells.

Supplier: STEMCELL Technologies

For detection and measurement of human immunoglobulin G.

Supplier: STEMCELL Technologies

For detection and measurement of mouse immunoglobulin M.

Supplier: STEMCELL Technologies

Diluent for ELISA samples, standards, and detection antibodies.

Supplier: STEMCELL Technologies

Antibiotic for selecting transfected prokaryotic and eukaryotic cells.

Supplier: STEMCELL Technologies

For the culture of human mesenchymal stem cells.

Supplier: STEMCELL Technologies

Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand and Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe and Crump; Hulstrand and Houston).

Supplier: STEMCELL Technologies

Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch et al.). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei and Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete et al.). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson et al.). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang et al.).

Supplier: STEMCELL Technologies

Serum-free media for generation and maturation of branching lung organoids from human ES and iPS cells.

Supplier: STEMCELL Technologies

Base methylcellulose medium for mouse cells.

Supplier: STEMCELL Technologies

Methylcellulose-based medium with recombinant cytokines (without EPO) for mouse myeloid progenitor cells.

Supplier: STEMCELL Technologies

Immunodensity isolation of untouched myeloid cells for lineage-specific chimerism analysis.

Supplier: STEMCELL Technologies

Kit for enzymatic dissociation of adult mouse and rat CNS tissue.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse CD45, PerCP-Cy5.5-conjugated.

Supplier: STEMCELL Technologies

Dulbecco's Modified Eagle's Medium (DMEM) with 1000 mg/L D-glucose.

Supplier: STEMCELL Technologies

Methylcellulose-based medium without cytokines for mouse cells.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2b antibody against human OCT4 (OCT3), PE-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG3, kappa isotype control antibody, PE-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41, FITC-conjugated.

Supplier: STEMCELL Technologies

Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions. After LIF binds to the LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling (Auernhammer and Melmed; Suman et al.). LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype (Niwa et al.). Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment (Auernhammer and Melmed; Suman et al.). Human LIF can be used for the maintenance of mouse embryonic stem cells; however, mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive (Dahéron et al.). LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes (Metcalfe). LIF is also secreted by mesenchymal stromal cells, where it supports hematopoiesis and immune modulation (Nasef et al.).

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse CD24, PE-conjugated.

Supplier: STEMCELL Technologies

Pre-aliquoted methylcellulose-based medium with recombinant cytokines for human cells. 24×3 ml vials.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD138 (syndecan-1), APC-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee, horse CD38, biotin-conjugated.

Supplier: STEMCELL Technologies

Rat (WI) monoclonal IgG2b antibody against mouse TER119.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2).

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220), PerCP-Cy5.5-conjugated.

Supplier: STEMCELL Technologies

Serum- and BPE-free medium for expansion of primary human airway epithelial cells.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD25, PE-conjugated.