2458 Results for: "Stemcell Technologies"

Supplier: STEMCELL Technologies

The EasySep™ magnet is designed for cell separation procedures using EasySep™ reagents.

Supplier: STEMCELL Technologies

Integrated workflow containing tools to isolate and expand CD34+ progenitor cells from peripheral blood and their subsequent reprogramming to iPS cells.

Supplier: STEMCELL Technologies

Use autotaxin (ENPP2) to catalyze the production of lysophosphatidic acid (LPA), a potent mitogen that can evoke growth factor-like responses (Moolenaar and Corven), from lysophospholipids in extracellular fluids. Autotaxin is a secreted glycoprotein that belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) family, containing two N-terminal somatomedin B (SMB)-like domains, a central phosphodiesterase (PDE) domain with an active catalytic site, and a C-terminal nuclease-like (NUC) domain (Nishimasu et al.). Dysregulation of autotaxin and LPA receptors is implicated in cancer (Tigyi et al.), fibrosis (Ninou et al.), neurological disorders (Roy et al.), and other inflammation-associated conditions. Both Autotaxin and LPA are overexpressed in many cancers and can promote cell proliferation, migration, and resistance to apoptotic death (Tigyi et al.). Autotaxin was also found to catalyze the production of cyclic phosphatidic acid (CPA), an analog of LPA, which has anti-mitogenic and inhibitory effects on tumor cell invasion and metastasis (Fujiwara). This protein contains a His-residue tag at the amino end of the polypeptide chain. For consistency and reproducibility across your applications, Autotaxin from STEMCELL comes lyophilized with ≥ 85% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.

Supplier: STEMCELL Technologies

Culture medium kit for expansion of human NK cells.

Supplier: STEMCELL Technologies

Serum-free and xeno-free base medium for the expansion of NK cells.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of particle-free human CD19+ cells.

Supplier: STEMCELL Technologies

For neural differentiation of mouse and human ES and iPS cells.

Supplier: STEMCELL Technologies

Culture supplement for the differentiation of human naïve CD4+ T cells into Th2 cells.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of eosinophils directly from whole blood

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1, kappa isotype control antibody, PE-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD184 (CXCR4), APC-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against mouse CD19, PerCP-Cy5.5-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, sooty mangabey CD123 (IL-3Rα), PE-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse Gr-1 (Ly-6G/Ly-6C), PE-conjugated.

Supplier: STEMCELL Technologies

Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human pluripotent stem cells (Xu et al.; Kang et al.), stimulates human pluripotent stem cells to form neural rosettes (Zhang et al.), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga et al.). This version of bFGF is the full-length bFGF protein encoded by the human FGF2 gene consisting of 154 amino acid residues. This product is animal component-free.

Supplier: STEMCELL Technologies

cGMP, enzyme-free cell dissociation reagent.

Supplier: STEMCELL Technologies

Reliably isolate mononuclear cells from peripheral blood, cord blood, or bone marrow with Lymphoprep™, a cost-effective alternative to Ficoll-Paque™.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human CD8+ T cells.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human peripheral blood mononuclear cells from whole blood

Supplier: STEMCELL Technologies

cGMP, feeder-free maintenance medium for human ES and iPS cells.

Supplier: STEMCELL Technologies

Cas9 nuclease (4 μg/μl) for the generation of double-strand breaks in CRISPR-Cas9 genome editing.

Supplier: STEMCELL Technologies

Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi et al.). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause et al.), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba et al.).

Supplier: STEMCELL Technologies

Stimulating T cells with EBV (HLA Class I Control) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. EBV (HLA Class I Control) Peptide Pool is a lyophilized mixture of 26 peptides from Epstein-Barr virus (EBV), and consists of defined HLA class I-restricted T cell epitopes. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development. For consistency and reproducibility across your applications, CMV peptide pool from STEMCELL has a purity ≥95%.

Supplier: STEMCELL Technologies

Complete kit for optimization of genome editing in human cells.

Supplier: STEMCELL Technologies

Collagenase/dispase blend with high collagenase and high caseinase activity.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of particle-free mouse cells labeled with PE-conjugated antibodies.

Supplier: STEMCELL Technologies

Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick et al.). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata et al.).

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human SSEA-5, FITC-conjugated.

Supplier: STEMCELL Technologies

A cell-permeable calcium dye that exhibits fluorescence upon increasing Ca2+ concentrations.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD138 (syndecan-1), APC-conjugated.