3039 Results for: "Southern Biotechnology"

Supplier: Southern Biotechnology

CD8 is a 33 kDa transmembrane glycoprotein expressed as either a CD8αα homodimer or CD8αβ heterodimer. It is expressed on the “cytotoxic/suppressor” subpopulation of peripheral T cells. CD8 functions primarily as a coreceptor with MHC class I-restricted TCR’s in antigen recognition.

Supplier: Southern Biotechnology

CD14 is a 55 kDa glycosphosphatidylinositol (GPI)-anchored single chain glycoprotein. It is expressed on monocytes, macrophages, dendritic cells, and Langerhans cells. It is also weakly expressed on neutrophils. CD14 appears to be involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes.

Supplier: Southern Biotechnology

Purified Anti-Human IgG4 pFc' antibody for use in ELISA, flow cytometry, immunohistochemistry, surface plasmon resonance, western blotting, and immunoprecipitation assays.

Supplier: Southern Biotechnology

CD19 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at all stages of B cell differentiation except terminally differentiated plasma cells. It is also present on the cell surface of follicular dendritic cells. CD19 associates with CD21, CD81, Leu 13 and/or MHC Class II molecules to form a signal transduction complex on the B cell surface. This signaling complex modulates the activation threshold for the B cell antigen receptor (BCR).

Supplier: Southern Biotechnology

CD79 is a disulfide-linked heterodimer composed of an α chain (CD79a) and a β chain (CD79b) that associates non-covalently with membrane immunoglobulin to form the B cell receptor (BCR) complex. Its expression is restricted to B lymphocytes first appearing on the surface at the pro-B cell stage and remaining through all stages of B cell differentiation prior to plasma cells. Crosslinking of the BCR leads to B cell activation. The monoclonal antibody CB3-1 reacts with the β chain of CD79.

Supplier: Southern Biotechnology

Rabbit F(ab')2 Anti-Rat IgG(H+L)-HRP antibody with minimal reactivity to human proteins for use in ELISA and immunocytochemistry assays.

Supplier: Southern Biotechnology

Goat Anti-Rhesus IgG(H+L)-AP antibody for use in ELISA, immunocytochemistry, and western blotting assays.

Supplier: Southern Biotechnology

Rabbit Anti-Rat IgG(H+L)-AP antibody for use in ELISA, immunohistochemistry, and western blotting assays.

Supplier: Southern Biotechnology

PE Anti-S-Tag for use in fluorescent assays.

Supplier: Southern Biotechnology

Mouse IgA-PE for use as a control in flow cytometry assays.

Supplier: Southern Biotechnology

Biotin Anti-Type VI Collagen antibody for use in ELISA, immunohistochemistry / immunocytochemistry, electron microscopy, and western blotting assays.

Supplier: Southern Biotechnology

Biotin Anti-Human IL-10 antibody for use in immunohistochemistry, ELISA, ELISpot, western blotting, and multiplex assays.

Supplier: Southern Biotechnology

Biotin Anti-Human IL-5 antibody for use in flow cytometry, ELISA, and immunohistochemistry / immunocytochemistry assays.

Supplier: Southern Biotechnology

Goat Anti-Mouse Lambda-HRP antibody for use in ELISA, immunohistochemistry / immunocytochemistry, western blotting, and ELISpot assays.

Supplier: Southern Biotechnology

The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear. There is an aberrant expression of fibrillin in Marfan syndrome. The epitope for the monoclonal antibody 11C1.3 has been found to be within exons 18-20 (a.a. 723-909).

Supplier: Southern Biotechnology

CD45RC represents an exon C-dependent isoform of CD45 glycoprotein. It is expressed at high density on all B lymphocytes, at intermediate density on most CD8+ splenic T cells, and on two subpopulations of CD4+ splenic T cells with high and low density of expression. CD45RC is also present on a small subset of thymocytes.

Supplier: Southern Biotechnology

CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.

Supplier: Southern Biotechnology

Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

Supplier: Southern Biotechnology

CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. The monoclonal antibody H1.2F3 augments PMA-induced T-cell proliferation and induces redirected lysis of Fc receptor-bearing target cells by NK cells.

Supplier: Southern Biotechnology

CD19 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at all stages of B cell differentiation except terminally differentiated plasma cells. It is also present on the cell surface of follicular dendritic cells. CD19 associates with CD21, CD81, Leu 13 and/or MHC Class II molecules to form a signal transduction complex on the B cell surface. This signaling complex modulates the activation threshold for the B cell antigen receptor (BCR).

Supplier: Southern Biotechnology

CD42b, also known as GPIbα, is a two-chain membrane glycoprotein that forms a noncovalent complex with CD42a (GPIX) on the surface of platelets and megakaryocytes. Binding of the GPIb/GPIX heterodimer to von Willebrand factor bound to exposed subendothelial surfaces is essential for platelet adhesion at sites of injury.

Supplier: Southern Biotechnology

Purified Anti-Human IgM antibody for use in ELISA, flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, stimulation, and multiplex assays.

Supplier: Southern Biotechnology

Feline CD4, a member of the immunoglobulin superfamily of cell surface receptors, is a type I transmembrane glycoprotein that is expressed on the helper/inducer subpopulation of peripheral T lymphocytes. It is present on approximately 55% of thymocytes, 15% of splenocytes, 40% of lymph node cells, and 25% of peripheral blood lymphocytes. CD4 functions as an accessory molecule in the recognition of foreign antigens in association with MHC Class II antigens by T cells.

Supplier: Southern Biotechnology

Goat Anti-Mouse IgG2b-TRITC antibody with minimal reactivity to human proteins for use in immunohistochemistry / immunocytochemistry assays.

Supplier: Southern Biotechnology

Purified Anti-Mouse TNF-alpha antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, ELISA, and ELISpot assays.

Supplier: Southern Biotechnology

Goat F(ab')2 Anti-Mouse IgG(H+L)-FITC antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

Supplier: Southern Biotechnology

Purified Mouse IgM for use as a control in flow cytometry, immunohistochemistry, and in vitro assays and as a standard in ELISA.

Supplier: Southern Biotechnology

Mouse IgG-Biotin for use as a control in flow cytometry and immunohistochemistry / immunocytochemistry assays.

Supplier: Southern Biotechnology

Goat Anti-Mouse IgG-AP antibody with minimal reactivity to human proteins for use in ELISA, immunohistochemistry / immunocytochemistry, western blotting, and ELISpot assays.

Supplier: Southern Biotechnology

Mouse F(ab’)2 IgG1-FITC for use as a control in flow cytometry and immunohistochemistry assays.