"Peprotech"

Supplier: Peprotech

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. The human LIGHT gene encodes for a 240 amino acid type II transmembrane protein containing a 37 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 182 amino acid extracellular domain. Recombinant Human LIGHT has a calculated mass of 19.3 kDa, containing 177 amino acid residues. Due to glycosylation, LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.

Supplier: Peprotech

Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing bonds at, or adjacent to, specific residues or a specific sequence of residues contained within the substrate protein or peptide. Proteases play an important role in most diseases and biological processes including prenatal and postnatal development, reproduction, signal transduction, the immune response, various autoimmune and degenerative diseases, and cancer. They are also an important research tool, frequently used in the analysis and production of proteins. Carboxypeptidase-B sequentially cleaves C-terminal K and R residues. Recombinant Rat Carboxypeptidase-B is a 35.1 kDa protein consisting of 307 amino acids.

Supplier: Peprotech

TWEAKR belongs to the TNF family of transmembrane proteins, and contains a cytoplasmic "death domain," which can activate a cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either membrane-anchored or soluble TWEAK. Recombinant Human TWEAK Receptor is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full-length TWEAKR protein.

Supplier: Peprotech

Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis. Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine Eotaxin-2 (CCL24). Anti­Murine Eotaxin-2 (CCL24)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human CTGFL/WISP-2. Anti­Human CTGFL/WISP-2­specific antibody was purified by affinity chromatography employing an immobilized Human CTGFL/WISP-2 matrix.

Supplier: Peprotech

Monoclonal AntibodyProduced in BALB/c x C57BL/6 F1-mice immunized with highly pure Recombinant Human Eotaxin (CCL11). Anti­Human Eotaxin (CCL11)­specific antibody was purified from ammonium sulfate precipitation followed by ion exchange chromatography.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human Eotaxin-3 (CCL26). Anti­Human Eotaxin-3 (CCL26)­specific antibody was purified by affinity chromatography employing an immobilized Human Eotaxin-3 matrix.

Supplier: Peprotech

Monoclonal AntibodyProduced in mice immunized with highly pure Recombinant Human BMP-7. Anti­Human BMP-7­specific antibody was purified from cell culture by Protein G affinity chromatography.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human TPO. Anti­Human TPO­specific antibody was purified by affinity chromatography employing an immobilized Human TPO matrix.

Supplier: Peprotech

CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/BSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung, and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Recombinant Murine Cardiotrophin-1 is a 21.3 kDa protein consisting of 202 amino acid residues.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human VEGF. Anti­Human VEGF­specific antibody was purified by affinity chromatography employing an immobilized Human VEGF165 matrix.

Supplier: Peprotech

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Human VEGF 165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Supplier: Peprotech

Monoclonal AntibodyProduced in mice immunized with highly pure Recombinant Human BMP-4. Anti­Human BMP-4­specific antibody was purified from cell culture by Protein G affinity chromatography.

Supplier: Peprotech

PeproTech's Human β-NGF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human β-NGF in a sandwich ELISA format.

Supplier: Peprotech

PeproTech's Human IFN-γ ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human IFN-γ in a sandwich ELISA format.