97963 Results for: "Molecular+Biology+Reagents"

Supplier: Genetex

In response to G-protein couples receptor stimulation, the cGMP can be produced from GTP by either cytoplasmic, soluble guanylate cyclase (sGC) are heterodimers ('N & 'O polypeptide chains), that are stimulated by nitric oxide and carbon monoxide or by particulate membrane-bound guanylyl cyclases which are activated by a complex mechanism by natriuretic peptides. Particulate GC (PGCs) have 7 different isoforms, PGC-A through PGC-G and are expressed in most tissues in isoform specific manner. There is significant structural homology among various PGCs, there is a large N-terminal extracellular domain (ECD), a single TMD and a large intracellular domain with protein kinase activity (KLD), a C-terminal catalytic domain (CD) and in between is a dimmerization domain (DD). The particulate GC-D, also known as olfactory gunylate cyclas, is specifically expressed in a subpopulation of olfactory sensory neurons.

Supplier: Restek

Restek Rt®-Alumina BOND columns are highly selective for C1 to C5 hydrocarbons and separate all saturated and unsaturated hydrocarbon isomers above ambient temperatures.

Supplier: Genetex

Animal models of human aging which display the characteristic diseases associated with aging provide insight into the cause of such diseases. Recently a transgenic mouse model, called Klotho, with several premature aging phenotypes has been described. They display premature aging phenotypes such as Osteoporosis, age related skin changes, ectopic calcifications, atrophy of genital organs and thymus, emphysema and short life span. KL protein associated with the Klotho mutation is a 1014 amino acid long peptide. It has a putative signal sequence at its N-terminus and a single transmembrane domain near its C-terminus, which is postulated to anchor it to the membrane. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway. KL has been reported to be localized on the cell surface when expressed on Cho cells. Human kl cDNA is expected to encode a protein of 1012 amino acids.

Supplier: MONTANA MOLECULAR MS

KIT ASSAY GREEN PIP2 SENSOR BACMAM 60ML

Supplier: MOLTOX Molecular Toxicology

MINIMAL GLUCOSE AGAR PLATE 12 WELL PLATE

Supplier: MOLECULAR DIMENSIONS INC MS

PACT PREMIER PH/ANION/CATN SCRN 96X10ML

Supplier: MONTANA MOLECULAR MS

ASSAY KIT RATIOMETRC CELL STRES RED 60ML

Supplier: MAINE MOLECULAR QUALITY CONTROLS MS

KIT INTROL TB PANEL BOTTLES-1ML

Supplier: MOLTOX Molecular Toxicology

NADPH REGENSYS B PLUS LYOPHILIZED 15ML

Supplier: Molecular Innovations

FACTOR IX SODIUM CITRATE MOUSE 0.1 ML

Supplier: MOLTOX Molecular Toxicology

TRYPTIC SOY AGAR 150MM PLATE 75 ML/PLATE

Supplier: MOLTOX Molecular Toxicology

BRAIN HEART INFUSION AGAR PLATE 20 ML/PL

Supplier: Molecular Innovations

RECOM HUMAN FACTOR BETA-XIIA >95% 0.1 MG

Supplier: MAINE MOLECULAR QUALITY CONTROLS MS

CONTROL KIT EPLEX RP 10 TUBES X 200 UL

Supplier: MOLECULAR DIMENSIONS INC MS

LIGAND FRIENDLY SCREEN HT-96 96 X 1 ML

Supplier: MOLECULAR DIMENSIONS INC MS

PACK VALUE MEMGOLD COMBO HT-96 192X1ML

Supplier: MOLTOX Molecular Toxicology

LB AGAR PLATE W/20UG/ML TETRACYCLINE (LE

Supplier: MOLECULAR DIMENSIONS INC MS

SODIUM 2HYDROGEN PHOSPHT PH 9.2 1M 200ML

Supplier: MOLTOX Molecular Toxicology

BRILLIANT GREEN AGAR/XLD AGAR BI-PLATE 1

Supplier: MOLTOX Molecular Toxicology

DEMI FRAZER BROTH 10ML/TUBE 10 TUBESBX

Supplier: MOLECULAR DIMENSIONS INC MS

WIZARD CLASSIC 3 4 HT-96 96 X 1.7 ML

Supplier: MOLECULAR DEVICES, LLC MS

TIP PIPET 3 CLEAR 96-WELL 10 RACK 200UL

Supplier: MOLTOX Molecular Toxicology

S9 GSH PB/BNF 0.154 M KCL FROZEN 5ML

Supplier: MONTANA MOLECULAR MS

KIT GREEN GI CADDIS CAMP SENSOR CMV 60ML

Supplier: Genetex

Brutons tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-located Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of Btk is negatively regulated by PKCbeta through phosphorylation of Btk at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/Btk inhibitory signal is likely to be a key determinant of the B-cell receptor signaling threshold to maintain optimal Btk activity.

Supplier: Genetex

Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (Cu/Zn SOD) and manganese-containing SOD (Mn SOD). The Cu/Zn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from TNF-mediated apoptosis via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria. Mn SOD has also been shown to be a tumor suppressor in human breast cancer. Overexpression of this enzyme protects neurons from NMDA- and nitric oxide-induced neurotoxicity.

Supplier: MOLTOX Molecular Toxicology

TRYPTIC SOY AGAR SLANT 10 ML/TUBE 10BX

Supplier: DOJINDO MOLECULAR TECHNOLO MS

KIT LYSOSOMAL ACIDIC PH DETCT GRN/RD 1ST

Supplier: MOLECULAR DEVICES, LLC MS

WELL PLATE 2000UL SQUARE RND BTM 96 CS24

Supplier: Genetex

Alpha-methyacyl-CoA racemase (AMCR), is an enzyme invloved in beta oxidation of branched chain fatty acids and bile salt intermediates, and has recently been identified as a neomarker for prostate cancer, where it is over expressed. Several different isoforms have been reported that are produced either by extensinve alternatve splicing of 5 exons or by use of alternate initiation codons. At least 2 different transcripts, each derived from the 5 exons, have been reported, AMCR I and AMCR II. AMCR I is the most abundant form and enclodes for a 382 amino acid protein (42kDa). The other isoform AMCR II exhibits significnat homolgy to fumerate hydratase and encoes a 288 amino acid protein (32 kDa). Several other variants of IA and IIA isoforms are charcterized recently. The variants lack exon 3 and are designated as IB and IIB. In prostate tumor tissues that over express AMCR, both the A and B forms are over-expressed.