"G-Biosciences"

Supplier: G-Biosciences

G-Biosciences' Molecular Grade Water™ is suitable for use in molecular biology applications, PCR reactions, 2D electrophoresis and mass spectrometry.

Supplier: G-Biosciences

ZM-306416 is a VEGF receptor tyrosine kinase inhibitor with selectivity over FGFR-1 (KDR IC50=100 nM; FLT IC50=2 µM).

Supplier: G-Biosciences

Inhibits α-glucosidase I and II1,2. Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step3. May be used to produce an affinity ligand for purifying glucosidase 14. Was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line5.

Supplier: G-Biosciences

Hepatotrophic agent.

Supplier: G-Biosciences

MK-2206 is a potent and selective allosteric inhibitor of Akt (IC50s: Akt1=5 nM, Akt2=12 nM, Akt3=65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.

Supplier: G-Biosciences

T4 UvsX DNA recombinase mediates DNA strand exchange between homologous chromosomes.

Supplier: G-Biosciences

Anydrous DMSO [Dimethyl sulfoxide (CH3)2SO] is offered for the solubilization of the water insoluble cross-linkers and modification reagents.

Supplier: G-Biosciences

Suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT1. Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. Useful tool for probing the involvement of Wnt signaling pathway.

Supplier: G-Biosciences

An ATP-competitive inhibitor (IC50=99 nM) of the microtubule-severing AAA protein spastin, but not four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2)1. It impaired recovery of motor function in a mouse model of spinal cord injury2. Reverses the effects of 14-3-3 agonist fusicoccin A on neurite outgrowth and regeneration in vitro3. An interesting tool for the study of assembly, disassembly, or maintenance of microtubule-based cellular structures.

Supplier: G-Biosciences

Supplier: G-Biosciences

G-Biosciences' Well-Coated™ Protein A/G plates are designed to bind the constant (Fc) region of immunoglobulins ensuring that the antigen binding domain of the antibody is orientated away from the plate, offering maximum exposure of the binding site.

Supplier: G-Biosciences

Ferroptosis inhibitor (IC50=22 nM) that mitigates tissue injury in a mouse model of hepatic ischemia/reperfusion injury.1 It protected mouse myocardium against ischemia/reperfusion injury via a decrease in VDAC1 and restoration of GPX4 levels.2 Liproxstatin-1’s mechanism of activity has been attributed to its activity as a radical-trapping antioxidant.

Supplier: G-Biosciences

A highly economical dry bath incubator.

Supplier: G-Biosciences

Horizontal Electrophoresis Small is designed for easy and fast gel casting

Supplier: G-Biosciences

Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50=0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling1. Cell permeable.

Supplier: G-Biosciences

Inhibits TRPA1 channel.