13888 Results for: "Enzo Life Sciences"

Based on the dye cresyl violet and the cathepsin B ArgArg peptide recognition sequence, this kit allows the detection of cathepsin B activity in living cells by fluorescence microscopy.

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Anti-HSP90B1 Rat Monoclonal Antibody [clone: 9G10]

Supplier: Enzo Life Sciences

Used in Flow cytometry with species reactivity to Human, Mouse, Rat, Bovine, Canine, Chicken, Hamster, Guinea Pig, Monkey, Rabbit, Pig, Sheep, Xenopus.

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Anti-HSP90B1 Rat Monoclonal Antibody [clone: 9G10]

Supplier: Enzo Life Sciences

Glucose-regulated protein 94 (Grp94, gp96), an abundant resident endoplasmic reticulum (ER) lumenal stress protein, belongs to the Hsp90 family of molecular chaperones along with cytosolic Hsp90. Grp94 and such other resident soluble proteins of the ER as the Ca 2+ binding protein subfamily (CaBP, CaBPI, CaBP2 and calreticulin) possess the C-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL), a sorting signal considered responsible for the retention of these proteins in the pre-Golgi compartments. Stress conditions such as glucose starvation and heat shock which promote protein misfolding or unfolding increase Grp94 expression. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells. Grp94 and Hsp90 share high sequence identity and apparently identical adenosine nucleotide dependent modes of regulation, although previous data suggests that Hsp90 and Grp94 may differ in their nucleotide binding properties. The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket which also serves as the binding site for the Hsp90 inhibitors geldanamycin and radicicol. However, the molecular basis for adenosine nucleotide-dependent regulation of Grp94 remains unclear. Data supports a ligand dependent regulation of Grp94 function, and suggests a model whereby Grp94 function is regulated through a ligand -dependent conversion of Grp94 from an inactive to an active conformation.

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Anti-NA+/K+ ATPase alpha3 Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

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Human Native Cathepsin H (from Liver)

Supplier: Enzo Life Sciences

Isolated from human liver.

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Human Recombinant MMP3 (catalytic domain) (from E. coli)

Supplier: Enzo Life Sciences

Produced in E. coli.

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Human Recombinant Sirt5, His Tag

Supplier: Enzo Life Sciences

Highly active

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Human Recombinant PD-1

Supplier: Enzo Life Sciences

Produced in HEK cells. Extracellular domain of PD-1 (aa 25-167) containing a 5’-His-tag, V5 epitope tag spacer, and a FLAG-tag.

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Human Recombinant IFN-gamma

Supplier: Enzo Life Sciences

Produced in E.coli.

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Human Recombinant METAP2,HA Tag

Supplier: Enzo Life Sciences

Produced in insect cells. Recombinant, full-length (aa 1-478) methionine aminopeptidase 2 with an N-terminal hemagglutinin (HA) tag (YPYDVPDYA), cloned from human cDNA.

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Mito-TEMPO-H ≥95%

Supplier: Enzo Life Sciences

Spin probe for detection of mitochondrial superoxide.

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Necrox-5™ hydrochloride

Supplier: Enzo Life Sciences

Necrosis inhibitor

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Human Recombinant FasL (soluble)

Supplier: Enzo Life Sciences

Kills Fas-sensitive cells at concentrations of >1ng/ml in the presence of cross-linking enhancer.

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Adenovirus 40

Supplier: Enzo Life Sciences

From adenovirus type 40. Inactivated by 2 hours at 54°C.

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PKCζ PseudoSubstrate

Supplier: Enzo Life Sciences

Selective cell permeable inhibitor of PKCζ. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.

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Human Recombinant p62 (GST-tag),GST Tag

Supplier: Enzo Life Sciences

Produced in E. coli. Human p62 (1-440 aa) is fused to a N-terminal GST-tag.

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Human Recombinant Netrin 1

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The extracellular domain of human netrin-1 (aa 28-604) is fused at the N-terminus to a FLAG®-tag.

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Anti-DMPO Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG

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Mouse Recombinant Leptin, (2) (from E. coli)

Supplier: Enzo Life Sciences

Produced in E. coli.

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Angiotensin I/II (1-7)

Supplier: Enzo Life Sciences

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Human;Mouse Recombinant Thy-1 (RLE) (mouse):Fc

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The extracellular domain of mouse Thy-1 (aa 20-131) is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of mouse Thy-1 has been changed to RLE abolishing the binding of integrins.