77235 Results for: "Blood+Sampling+Device"

Supplier: Rockland Immunochemical

AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at  Ser 473 and Thr 308.  AKT is a cytoplasmic protein also known as AKT1, Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways.  AKT Exhibits tight control over cell proliferation and cell viability.  Overexpression or inappropriate activation of AKT is noted in many types of cancer.   AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phos-phorylated, AKT dissociates from the membrane and phos-phorylates targets in the cytoplasm and the cell nucleus.  AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.

Supplier: Genetex

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families. PDE8B exhibits cAMP PDE activity which was not inhibited by various PDE inhibitors, including IBMX. The cAMP hydrolytic activity was unaffected by cGMP, and no cGMP PDE hydrolysis has been detected. Northern blot analysis indicated that the 4.2-kb PDE8B mRNA was expressed at the highest levels in thyroid, and at lower levels in brain, spinal cord, and placenta.

Supplier: Thermo Scientific

Choose Thermo Scientific™ SureSTART™ 2 ml glass screw top vials, performance level 2, to ensure high quality data with an uninterrupted workflow in high-throughput applications using GC, HPLC/UHPLC, and single or triple quadrupole MS systems. Use level 2 vials for routine QA/QC applications, where the analyte levels are achievable or close to the method detection level. Available in clear and amber glass, these 2 ml screw top vials have very low metal content, extractables, and leachables and conform to high standards so that you can to meet your regulatory requirements. They are specification certified to ensure their physical dimensions and autosampler compatibility.

Supplier: Leica Microsystems

The Leica DM750 microscope is a versatile educational tool with precision optics, wireless camera for documentation and collaboration, Koehler illumination for clear observations, and user-friendly design. Perfect choice for educators to inspire students in exploring the microscopic world.

Supplier: Invitrogen

Thermo Scientific™ Pierce™ Premium Grade Sulfo-NHS-SS-Biotin is our highest quality formulation of this amine-reactive, cleavable biotinylation reagent, specially characterized for applications where product integrity and risk minimization are paramount. Sulfo-NHS-SS-biotin is used for cleavable attachment of biotin to protein and cell surface amines.

Supplier: Promega Corporation

Silica Membrane-based Wizard® Plus SV Minipreps System isolates plasmid DNA.

Supplier: Therapak, LLC

The Therapak® range of insulated shippers features five popular cooler sizes that are inventoried at two locations in the United States in order to provide a maximum three day ground or truck shipment turnaround to any point in the Continental U.S. The two facility approach offers freight economies to Eastern, Central, and Western region shipping points. Warehouses are located in Buford, Georgia and Claremont, California.

Supplier: Sartorius

These MCE series essential user interface balance was a large, high-contrast touch display with factory-installed essential weighing applications for easy operation.

Supplier: Antyila Scientific

The PCRmax Eco 48 utilises patented block and optical technologies to deliver extreme speed, sensitivity and data quality.

Supplier: VWR

Fluorescent DNA Quantitation Kit uses the fluorescent bisBenzimide H33258 dye to bind to AT sequences of the minor groove of double-stranded DNA

Supplier: Invitrogen

Thermo Scientific Pierce Premium Grade Sulfo-SMCC is our highest quality formulation of amine-to-sulfhydryl crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.

Supplier: Labconco

Cell logic Class II, Type A2 Biosafety Cabinets (BSCs) offer comprehensive personnel, product and environmental protection from hazardous particulates, including risk group agents requiring BSL 1-4 containment. Cell logics are designed to meet the specific needs of cell research. Models feature a modified sash to accommodate a microscope and/or a temperature-controlled work area on the work surface to maintain cell viability. All models ensure the highest standard of safety and performance.

Supplier: INDIGO BIOSCIENCES INC MS

Eliminate weeks of cell culture while achieving superior sensitivity with reproducible results from this all-inclusive cell-based luciferase reporter assay. INDIGO’s Human ER Reporter Assays Panel All-inclusive Cell-Based Luciferase Reporter Assay Kit includes reporter cells for each ER, optimized cell culture medium, a medium for diluting test compounds, 17-β-estradiol control agonist, stable-glow luciferase detection reagent, detailed protocol, protocol quick guide, and a cell culture-ready assay plate in strip-well format.

Supplier: Quantabio

Superior sensitivity for viral RNA detection.

Supplier: Stirling Ultracold

Ultra-low temperature freezer featuring a free-piston Stirling engine.

Supplier: Quantabio

Kits offer a convenient and highly sensitive solution for real-time reverse transcriptase PCR (qRT-PCR) of RNA templates using hybridization probe detection chemistries such as TaqMan® 5'-hydrolysis probes or molecular beacons on PCR instrument platforms.

Supplier: Sartorius

These MCE series essential user interface balance was a large, high-contrast touch display with factory-installed essential weighing applications for easy operation.

Supplier: Thermo Fisher Scientific

Get premium performance and flexibility with the Orion™ Versa Star Pro™ Meter with pH/ISE, Conductivity and RDO/DO Modules to measure up to four channels at once.

Supplier: Sheldon Manufacturing

SHEL LAB High Performance Ovens are engineered to meet the most critical temperature requirements. They are designed for continuous drying operations at temperatures up to 260 or 306 °C depending on the model. These ovens have rugged, welded construction with a double-walled, corrosion-resistant stainless steel interior and a powder-coated exterior.

Supplier: SPECTRUM TECHNIQUES, LLC

The ADVANCED Spectrometer System is capable for conducting a wide selection of spectroscopy experiments.

Supplier: MP Biomedicals

Deoxyribonuclease from beef pancreas, DNase I, was first crystallized by Kunitz. It is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3'. The average chain of limit digest is a tetranucleotide. DNase I acts upon single chain DNA, and upon double-stranded DNA and chromatin. In the latter case, although histones restrict susceptibility to nuclease action, over a period of time nearly all chromatin DNA is acted upon. According to Mirsky and Silverman, this could result from the looseness of histone attachment to DNA. They found that lysine-rich histones more effectively block DNase access to DNA than arginine-rich histones. Billing and Bonner suggest that DNase attacks the histone-free strand of chromatin DNA. Schmidt, et. al.indicate that hydrolysis of the histone-free region of DNA strands accounts for the initial rapid action of the enzyme on chromatin. Bollum reports degradation of synthetic homopolymer complexes by DNase I. The intracellular functions of the enzyme are probably controlled by a DNase inhibitor, which according to Lazarides and Lindberg is actin.

Supplier: Promega Corporation

The QuantiFluor RNA System contains a fluorescent RNA-binding dye that enables sensitive quantitation of small amounts of RNA in solution.

Supplier: Genetex

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zinc-endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. In addition, fibronectin-like repeats, a hinge region, and a C-terminal hemopexin-like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane-type MMP subfamilies. MMPs contain the motif His-Glu-X-X-His (X represents any amino acid) that binds zinc in the catalytic site, as well as another zinc molecule and two calcium molecules structurally. They fall within the matrixin subfamily and are EC designated 3.4.24.x. This group also contains astacin, reprolysin, and serralysin, as well as other more divergent metalloproteinases. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown.

Supplier: Sartorius

These MCE series essential user interface balances have a large, high-contrast touch display with factory-installed essential weighing applications for easy operation.

Supplier: Thermo Scientific Chemicals

Plant isolate kit is CTAB and chloroform based method to isolate total DNA (including genomic, mitochondrial, and chloroplast DNA) from a variety of plant species (including algae and cyanobacteria). The extracted DNA is suitable for routine PCR screening, real-time PCR, southern blotting, mapping, and RFLP.

Supplier: Zymo Research

Unique, magnetic bead surface chemistry that facilitates unparalleled cfDNA recovery from biofluids.

Supplier: Leica Microsystems

The Leica DM750 microscope is an advanced educational tool, with a wireless camera, Koehler illumination, and high-quality optics for clear observations. Enhance classroom experience with advanced imaging and comprehensive exploration.

Supplier: Genetex

Matrix Metalloproteinase 24 (MMP24, MT5MMP) has been described as a proteoglycanase, which is critical in the turnover of ECM (extracellular matrix) components in the brain. MMP24 contains a candidate signal sequence, a propeptide region, a potential furin recognition motif, a zinc-binding catalytic domain, a hemopexin-like domain, a 24-residue hydrophobic region, which acts as a potential transmembrane domain, and a short cytosolic domain. Unlike other MTMMPs, MMP24 (MT5MMP) sheds from the cell surface as soluble proteinases, allowing its versatility as both a cell bound and soluble proteinase in ECM remodeling processes. MMP24 is elevated in several tumor cell lines, and is also produced by some normal cell lines. It is predominantly expressed in the brain, indicating a role in nervous system development. MMP24 is also highly expressed during embryonic development. The mouse MMP24 gene maps to chromosome 2.

Supplier: Invitrogen

Thermo Scientific Heavy and Light Amino Acids are used to specifically analyze protein expression by mass spectrometry using stable isotope labeling with amino acids in cell culture (SILAC) quantification kits.

Supplier: Invitrogen

Thermo Scientific Heavy and Light Amino Acids are used to specifically analyze protein expression by mass spectrometry using stable isotope labeling with amino acids in cell culture (SILAC) quantification kits. Store at 2 - 8˚C.