"Biotium"

Supplier: Biotium

CD8 Monoclonal antibody, Clone: C8/468 + C8/144B, Host: Mouse, Species reactivity: Human, Isotype: IgG1, K, Conjugate: CF640R, Immunogen: A 13 amino acid synthetic peptide, C-term, Synonyms: T8/Leu-2, Application: IF, Size: 100uL

Supplier: Biotium

AMCA-X SE is an amine-reactive, UV-excitable, blue fluorescent dye.

Supplier: Biotium

CD309, also known as VEGFR2, KDR3, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGFR2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

Kappa Light Chain, Monoclonal antibody, Clone: L1C1, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Purified human Ig kappa chain (HP6053) & Human B-Lymphoma Cells (L1C1), Synonyms: Ig Kappa Chain C Region; IGKC, Size: 500uL

Supplier: Biotium

This MAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF betas inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Lambda Light Chain, Monoclonal antibody, Clone: ICO-106, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF405S, Immunogen: Purified IgG myeloma proteins coupled to polyaminostyren, Synonyms: BJP, Application: IF, Size: 500uL

Supplier: Biotium

This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. Epitope of this MAb is mapped between aa300-550. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

Mix-n-Stain™ antibody labeling kits dramatically simplify the process of labeling primary antibodies with fluorescent dyes or biotin

Supplier: Biotium

This antibody recognizes a protein of 57 kDa, identified as the L1 protein of human papilloma virus type 16 (HPV-16). It is the major capsid protein of HPV-16. Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies. The antibody reacts very strongly with formalin-fixed, paraffin-embedded tissues containing HPV-16 or -33; very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. It cross-This antibody recognizes HPV37.

Supplier: Biotium

Anti-IgG Rabbit Polyclonal Antibody (CF™ 594)

Supplier: Biotium

TNF alphA, Monoclonal antibody, Clone: TNF655, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant human TNF-alpha, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Hepatocyte Specific Antigen, Monoclonal antibody, Clone: HSA133, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: CF488A, Immunogen: SK-H1A9-2 human hepatocellular carcinoma cells, Application: Immunofluorescence, Size: 500uL

Supplier: Biotium

CELA3B Monoclonal antibody, Clone: CELA3B/1218, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recom human CELA3B protein, Synonyms: ELA3B, Elastase IIIB, Protease E, Application: IF, FC, Size: 100uL

Supplier: Biotium

MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: OJ79c, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: CF647, Immunogen: Recombinant human MUC18 protein, Application: Immunofluorescence, Immunohistology (formalin), Size: 500uL

Supplier: Biotium

BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NFkB activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.

Supplier: Biotium

This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.