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96 wells (1 kit) - ELISA is a sandwich enzyme immunoassay for the quantitative measurement of C-terminal telopeptides of Type l collagen.

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96 wells (1 kit) - ELISA is a sandwich enzyme immunoassay for the quantitative measurement of cystatin C.

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ELISA, Interleukin-12, High Sensitivity, Human, 96 wells (1 kit)

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Guanylin is thought to modulate intestinal water/electrolyte transport in a paracrine mode reported the nucleotide sequence of the gene, the characteristics of its circulating molecular form, and its localization in enterochromaffin cells of the gut. The gene, approximately 2.6 kb in size, consists of 3 exons interrupted by 2 introns. The hormonal form of guanylin is a 94-amino acid peptide with a molecular mass of 10.3 kDa. Guanylin is synthesized by gut enterochromaffin cells as a prohormone of 115 amino acids and is processed to the molecular form of 94 amino acids circulating in the blood. Total 104 AA. MW: 11,5 kDa (calculated). UniProtKB acc.no. Q02747 (Val22-Cys115). N-terminal His-tag (10 extra AA). Protein identity confirmed by LC-MS/MS.

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Prouroguanylin (about 9,7 kDa) is a biologically inactive form of uroguanylin circulating in a bloodstream.

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Total 522 AA. Mw: 59,5 kDa (calculated) C-terminal his-tag (6 extra AA) UniProt entry Q9UEF7–2, Isoform 2 (secreted)

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The human glutathione peroxidase 1 ELISA is to be used for the in vitro quantitative determination of human glutathione peroxidase 1 (GPX1) in cell lysates or cellbased assays (screening).

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Total 100 AA. MW: 11.42 kDa (calculated). UniProtKB acc.no. P06703. N-Terminal His-tag, 10 extra AA

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Trefoil factor 2 (TFF2) (PSP – pancreatic spasmolytic polypeptide) is a small secreted protein with a molecular weight of 12 kDa. It belongs to the TFF protein family that is characterized by a clover leaf–like disulphide structure named the TFF domain, which is created by 6 cysteines forming three intramolecular bonds. TFF2 contains two trefoil domains and has a very compact structure which may account for its extremely high resistance against the harsh environment in the gastrointestinal tract. The most abundant expression of TFFs is found in GI tract (especially in stomach, colon and pancreas), where they are co-localised with mucins. TFF2 is usually co-localised with MUC6 and probably mediates mucin cross-linking and stabilization of the mucin layer as do the other members of the TFF family.

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IL-10 is an immunoregulatory protein produced by a number of cell lineages, including TH2 cells, B-cells and activated monocytes.

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Total 166 AA. MW: 18.4 kDa (calculated). UniProtKB acc. No. O43508 (Ser94–His249). N-terminal linker (2 extra AA), C-terminal linker (2 extra AA) and C-terminal His-tag (6 extra AA). Protein identity confirmed by LC-MS/MS.

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Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01% of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned; AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal.

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Collectrin regulates insulin secretion on the surface of pancreatic beta cells, and mediates amino acid transport on renal tubular epithelium. The extracellular domain is cleaved off the surface of beta cells.

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L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation

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The FGFs are a family of more than 20 small (~17–26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response.

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Total 108 AA. MW: 12.66 kDa (calculated). UniProtKB acc.no. Q99584. N-Terminal His-tag, 10 extra AA

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Trail R3 antagonizes TRAIL-induced apoptosis.

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Total 309 AA. MW: 34.49 kDa (calculated). UniProtKB acc.no. Q15493. N-terminal His-tag (10 extra AA).

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Human Lecithin: cholesterol acyltransferase (LCAT) is a glycoprotein with a molecular mass of approximately 58 kDa. It is the key enzyme responsible for esterification of free cholesterol to cholesteryl esters in circulating plasma lipoproteins, primarily in high density lipoprotein (HDL). The tertiary structure of LCAT is maintained by two disulfide bridges, similar to lipases and other proteins of the α/β hydrolase fold family. Mature LCAT protein is synthesized from a 440 residue precursor by following cleavage of a 24 residue signal peptide. The mature protein contains 416 amino acids and is heavily N-glycosylated. LCAT is abundant in blood plasma and it is present in other organs, including liver, brain and testes. In plasma LCAT is associated with ApoD which frequently co-purify.

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Total 462 AA. MW: 51.0 kDa (calculated). UniProtKB acc. No. P01019 (Asp34-Ala485). C-terminal linker (2 extra AA) and C-terminal FLAG-tag (8 extra AA). Protein identity confirmed by LC-MS/MS.

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IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naïve but not memory CD4+ T cells.

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Human thyrostimulin ranks among the glycoprotein hormone family. These hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. The alpha-subunit combines with four distinct beta-subunits giving rise to four biologically active hormones in human: FSH, LH, TSH, and CG. FSH, LH, and TSH, mainly expressed in the anterior pituitary, are essential for coordinated endocrine regulation in the hypothalamus- pituitary axis and show to activate specific G protein–coupled receptors in the thyroid (TSH receptor) and gonads (LH and FSH receptors), respectively.

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ULBP5 acts as a ligand for the NKG2D receptor on the surface of NK cells. ULBP ligands are produced by virally infected cells and tumours. Stimulation of NKG2D contributes to anti-tumour and anti-viral immune responses of NK cells. ULBP5 is expressed in two variants, as a membrane and soluble isoform.

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The Heat shock protein 70(HSP70) family was found in many intracellular compartments. Members of this protein occur in chloroplasts, endoplasmic reticulum, mitochondria, and cytosol. These proteins are induced by a variety of biological stresses, including heat stress, in every organism. HSP70 serves a variety of roles: It acts as molecular chaperones facilitating the assembly of multi-protein complexes, It participates in the translocation of polypeptides across cell membranes and to the nucleus It aids in the proper folding of nascent polypeptide chains. HSP70 is mitochondrial import machinery and plays key roles in the cytosolic endoplasmic reticulum. Recently, extracellular localized HSP have been found to play key roles in the induction of a cellular immune response.

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Total 286 AA. MW: 33.3 kDa (calculated). UniProtKB acc.no. Q6R556. N-terminal His-tag, 10extra AA

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5α-Androstane-3α, 17β-diol glucuronide is a C19 steroid produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT).

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Clusterin is a 75–80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid, but truncated forms targeted to the nucleus have also been identified. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the alpha and beta chains. These are assembled anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil alpha-helices and three predicted amphipathic alpha-helices. Clusterin is a heavily N-glycosylated protein.

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Quality control test, Indirect ELISA – to determine titer of the antibody , SDS PAGE – to determine purity of the antibody, and BCA - to determine quantity of the antibody.

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EndoTrap HD is based on hydrophilic, dimensionally stable affinity matrix with excellent pressure/flow characteristics.

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96 wells (1 kit) - ELISA is a competitive enzyme immunoassay for the quantitative measurement of CTX-I.