Human Recombinant IL-17A (from E. coli)
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Product Details & Documents
Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.
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- Low endotoxin
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Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells.
Caution: For research use only.
Documents
VWR Cytokine and Growth Factors.pdf
Product Literature
Specifications
Specifications
- Pack type:Vial
- Size:1 mg
- Storage Conditions:–20 °C
- Molecular Weight:15.7/31.3 kDa
- Protease-free:N
- Reconstitution Instructions:Sterile water at 0.1 mg/ml
- Endotoxin Level:Low
- Purity:≥95%
- Carrier-Free:Y
- Source:E. coli
- Nuclease-free:N
- Biological Activity:Bioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mg
- Protein/Peptide Type:Recombinant
- Gene ID:Q16552
- Formulation:0.1% trifluoroacetic acid (TFA)
- Protein/Peptide Name:IL-17A
- Endotoxin-free:N
- Species:Human
- Protein Function:Cytokine
- Animal-Free:N
- Tested Applications:Bioassay
- Grade:RUO
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.1
- Sequence:MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- Cat. No.:77751-816
- Shipping Temperature:RT
- Protein Synonyms:IL-17|CTLA-8
- Conjugation:Unconjugated
Specifications
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