UvsY is the phage T4 recombination mediator protein, and structural and biophysical studies provide insights into its role in T4 homologous recombination. During T4 homologous recombination, the UvsX recombinase must compete with the prebound gp32 single-stranded binding protein for DNA-binding sites and T4 UvsY Protein stimulates this filament nucleation event. UvsY is a 15.8 kDa protein with properties that are consistent with its role as mediator; it stimulates the DNA-dependent ATPase activity of UvsX, lowers the critical concentration of UvsX that is required for activity, and promotes strand exchange (2, 3).

• In RPA, promotes the UvsX-catalyzed strand invasion reaction

• Recruits to ssDNA - gp 32 complexes to site of recombination
• Promotes the release of gp 32
• Favors the binding of UvsX

  Shipping temperature: Dry ice

Optimal for lyophilization: Perfect for freeze-drying into diagnostic kits, ensuring stability and performance for point-of-care tests like molecular diagnostics.

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