PEmax enzyme is the purified recombinant Streptococcus pyogenes Cas9 nickase mutant (H840A)-Murine Moloney Leukemia Virus-Reverse Transcriptase (MMLV-RT) fusion protein3-4 containing a nuclear localization signal (NLS) at the C-terminal for targeting to the nucleus. This enzyme is designed to perform CRISPR prime-editing3-4. The physical purity of this enzyme is ≥85% as assessed by SDS-PAGE with Coomassie® blue staining.

Combine IG® PEmax enzyme with the PE pegRNA synthesis kit for a complete set of reagents for in vitro precision genome editing of your target sequence.

Manufactured under ISO 13485:2016 Quality Management certified standards.