Human/Mouse/Rat Recombinant BMP-2 (from E. coli)

Supplier: VWR International

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Supplier: VWR International

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About this item

Bone morphogenetic protein 2 (BMP-2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7.

High quality
Low endotoxin
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BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation. BMP-2 is also important during cardiac development and supports epicardial cell migration.

Caution:

For research use only.

Specifications

Conjugation:
Unconjugated
Protein Function:
Cytokine
Protein/Peptide Type:
Recombinant
Source:
E. coli
Species:
Human
Mouse
Rat
Storage Conditions:
At or below –20 °C
Endotoxin Content:
Endotoxin LAL (EU/µg) ≤0.1
Biological Activity:
Bioactivity assay: Alkaline phosphatase activity induced in ATDC-5 cells; ED₅₀ ≤250 ng/ml; Bioactivity ≥4.0×10³ units/mg
Gene ID:
P12643/P21274/P49001
Reconstitution Instructions:
Sterile water at 0.1 mg/ml
Endotoxin-free:
N
Carrier-Free:
Y
Protease-free:
N
Animal-Free:
Y
Protein Synonyms:
BMP-2A
Protein/Peptide Name:
BMP-2 (AF)
Purity:
≥95%
Molecular Weight:
13.0/26.1 kDa
Sequence:
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Endotoxin Level:
Low
Formulation:
0.1% Trifluoroacetic acid (TFA)
Nuclease-free:
N
Grade:
RUO
Shipping Temperature:
RT
Tested Applications:
Bioassay