Human Recombinant IL-10 (from E. coli)

Supplier: VWR International

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Supplier: VWR International

New Product

About this item

IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. Inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. Suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.

High quality Low endotoxin Lot-to-lot consistency Animal free Manufactured following GMP guidelines

Caution: For research use or further manufacturing only.

Specifications

Conjugation:
Unconjugated
Protein Function:
Cytokine
Protein/Peptide Type:
Recombinant
Source:
E. coli
Species:
Human
Storage Conditions:
At or below –20 °C
Endotoxin Content:
Endotoxin LAL (EU/µg) ≤0.05
Biological Activity:
Bioactivity assay: Proliferation of MC/9 ; ED50 ≤5 ng/ml; Bioactivity ≥5.0×10³ IU/µg
Gene ID:
P22301
Reconstitution Instructions:
Sterile water at 0.1 - 0.5 mg/ml
Endotoxin-free:
N
Carrier-Free:
Y
Protease-free:
N
Animal-Free:
Y
Protein Synonyms:
B-TCGF|CSIF|TGIF
Protein/Peptide Name:
IL-10
Purity:
≥97%
Molecular Weight:
18.8
Sequence:
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Endotoxin Level:
Low
Formulation:
10 mM Sodium phosphate, pH 7.5
Nuclease-free:
N
Grade:
GMP
Shipping Temperature:
Ambient