Human Recombinant IL-17A (from E. coli)
About this item
Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.
- High quality
- Low endotoxin
- Affordable
Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells.
Caution: For research use only.
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- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.
- High quality
- Low endotoxin
- Affordable
Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells.
Caution: For research use only.
Documents
VWR Cytokine and Growth Factors.pdf
Product Literature
Specifications for Product Family
Specifications
Specifications
- Catalog No:
- 77751-814
- 77751-816
- 77751-818
- 77751-820
- 77751-822
- Protein/Peptide Name:
- IL-17A
- IL-17A
- IL-17A
- IL-17A
- IL-17A
- Protein Synonyms:
- IL-17|CTLA-8
- IL-17|CTLA-8
- IL-17|CTLA-8
- IL-17|CTLA-8
- IL-17|CTLA-8
- Protein/Peptide Type:
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Protein Function:
- Cytokine
- Cytokine
- Cytokine
- Cytokine
- Cytokine
- Species:
- Human
- Human
- Human
- Human
- Human
- Source:
- E. coli
- E. coli
- E. coli
- E. coli
- E. coli
- Conjugation:
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Gene ID:
- Q16552
- Q16552
- Q16552
- Q16552
- Q16552
- Sequence:
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- Protease-free:
- N
- N
- N
- N
- N
- Animal-Free:
- N
- N
- N
- N
- N
- Nuclease-free:
- N
- N
- N
- N
- N
- Carrier-Free:
- Y
- Y
- Y
- Y
- Y
- Endotoxin-free:
- N
- N
- N
- N
- N
- Endotoxin Level:
- Low
- Low
- Low
- Low
- Low
- Endotoxin Content:
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Biological Activity:
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mg
- Purity:
- ≥95%
- ≥95%
- ≥95%
- ≥95%
- ≥95%
- Grade:
- RUO
- RUO
- RUO
- RUO
- RUO
- Formulation:
- 0.1% trifluoroacetic acid (TFA)
- 0.1% trifluoroacetic acid (TFA)
- 0.1% trifluoroacetic acid (TFA)
- 0.1% trifluoroacetic acid (TFA)
- 0.1% trifluoroacetic acid (TFA)
- Molecular Weight:
- 15.7/31.3 kDa
- 15.7/31.3 kDa
- 15.7/31.3 kDa
- 15.7/31.3 kDa
- 15.7/31.3 kDa
- Reconstitution Instructions:
- Sterile water at 0.1 mg/ml
- Sterile water at 0.1 mg/ml
- Sterile water at 0.1 mg/ml
- Sterile water at 0.1 mg/ml
- Sterile water at 0.1 mg/ml
- Storage Conditions:
- –20 °C
- –20 °C
- –20 °C
- –20 °C
- –20 °C
- Shipping Temperature:
- RT
- RT
- RT
- RT
- RT
- Tested Applications:
- Bioassay
- Bioassay
- Bioassay
- Bioassay
- Bioassay
Specifications
Product Family Options
Product Information
- Pack typeSizeAvailabilityPrice
- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.77751-814Protein/Peptide NameIL-17AProtein SynonymsIL-17|CTLA-8Protein/Peptide TypeRecombinantProtein FunctionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-FreeNNuclease-freeNCarrier-FreeYEndotoxin-freeNEndotoxin LevelLowEndotoxin ContentEndotoxin LAL (EU/µg) ≤0.1Biological ActivityBioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mgPurity≥95%GradeRUOFormulation0.1% trifluoroacetic acid (TFA)Molecular Weight15.7/31.3 kDaReconstitution InstructionsSterile water at 0.1 mg/mlStorage Conditions–20 °CShipping TemperatureRTTested ApplicationsBioassay - Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.77751-816Protein/Peptide NameIL-17AProtein SynonymsIL-17|CTLA-8Protein/Peptide TypeRecombinantProtein FunctionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-FreeNNuclease-freeNCarrier-FreeYEndotoxin-freeNEndotoxin LevelLowEndotoxin ContentEndotoxin LAL (EU/µg) ≤0.1Biological ActivityBioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mgPurity≥95%GradeRUOFormulation0.1% trifluoroacetic acid (TFA)Molecular Weight15.7/31.3 kDaReconstitution InstructionsSterile water at 0.1 mg/mlStorage Conditions–20 °CShipping TemperatureRTTested ApplicationsBioassay - Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.77751-818Protein/Peptide NameIL-17AProtein SynonymsIL-17|CTLA-8Protein/Peptide TypeRecombinantProtein FunctionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-FreeNNuclease-freeNCarrier-FreeYEndotoxin-freeNEndotoxin LevelLowEndotoxin ContentEndotoxin LAL (EU/µg) ≤0.1Biological ActivityBioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mgPurity≥95%GradeRUOFormulation0.1% trifluoroacetic acid (TFA)Molecular Weight15.7/31.3 kDaReconstitution InstructionsSterile water at 0.1 mg/mlStorage Conditions–20 °CShipping TemperatureRTTested ApplicationsBioassay - Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.77751-820Protein/Peptide NameIL-17AProtein SynonymsIL-17|CTLA-8Protein/Peptide TypeRecombinantProtein FunctionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-FreeNNuclease-freeNCarrier-FreeYEndotoxin-freeNEndotoxin LevelLowEndotoxin ContentEndotoxin LAL (EU/µg) ≤0.1Biological ActivityBioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mgPurity≥95%GradeRUOFormulation0.1% trifluoroacetic acid (TFA)Molecular Weight15.7/31.3 kDaReconstitution InstructionsSterile water at 0.1 mg/mlStorage Conditions–20 °CShipping TemperatureRTTested ApplicationsBioassay - Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.77751-822Protein/Peptide NameIL-17AProtein SynonymsIL-17|CTLA-8Protein/Peptide TypeRecombinantProtein FunctionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-FreeNNuclease-freeNCarrier-FreeYEndotoxin-freeNEndotoxin LevelLowEndotoxin ContentEndotoxin LAL (EU/µg) ≤0.1Biological ActivityBioactivity assay: Production of IL-6 from mouse 3T3 cells; ED50 ≤10 ng/ml; Bioactivity ≥1.0×10⁵ units/mgPurity≥95%GradeRUOFormulation0.1% trifluoroacetic acid (TFA)Molecular Weight15.7/31.3 kDaReconstitution InstructionsSterile water at 0.1 mg/mlStorage Conditions–20 °CShipping TemperatureRTTested ApplicationsBioassay
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