G-Biosciences' EndotoxinOUT™ is for the rapid removal of endotoxins and pyrogens (LPS, lipopolysaccharides) from samples.

G-Biosciences' EndotoxinOUT™ consists of 6% cross-linked agarose covalently linked to polymyxin B to bind and remove harmful pyrogens from a solution. Polymyxin B is a family of antibiotics that bind to the negatively charged site of the lipid A portion of bacterial lipopolysaccharide layer neutralizing the endotoxic activity. The covalently coupled agarose and polymyxin B is a stable matrix that resists leaching.

G-Biosciences' EndotoxinOUT™ is an ideal product for the clean up of buffers, cell culture media, protein solutions, nucleic acid (DNA) samples and pharmacological components. It's binding capacity is ≥9995 endotoxin units (EU) per milliliter resin from a 5 mL test containing 10,000 EU (≥99.95% removal). EndotoxinOUT™ is reusable at least 10 times.