CTGrade GMP rh PDGF-AA is a recombinant human protein that is produced from E. coli and is designed to support preclinical and clinical research, as well as commercial applications. 50 µg, 100 µg, and 1 mg sizes are available.

• High biological activity verified by a relevant bioactivity assay
• Low endotoxin levels
• ≥97% purity
• High lot-to-lot consistency

PDGF (platelet-derived growth factor)-AA serves as a crucial controller of cell growth, proliferation, and angiogenesis, and its synthesis is stimulated by signaling molecules, such as IL-1, IL-6, TNF-α, TGF-β, and EGF.

Differentiates neural progenitor cells derived from human pluripotent stem cells into oligodendrocyte precursor cells. Acts as a growth hormone that induces cell division in mesenchymal lineage cells like smooth muscle and glial cells. Releases from the alpha-granules of platelets when platelets adhere to injured tissue
Binds to cell surface receptor tyrosine kinases, specifically PDGFR-α and PDGFR-β.

For the development of advanced cell therapies, FUJIFILM Irvine Scientific is your one-stop-shop for the high-performing recombinant proteins required for expansion, proliferation, differentiation, and activation of immune and stem cells. Our CTGrade GMP recombinant proteins can be purchased separately or as a bundle with one of our high-performing PRIME-XV or classical media for a cost-effective solution.

The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance. The CTGrade GMP products are manufactured in a facility that does not use or process beta-lactam containing materials. No animal- or human-derived materials were used during manufacturing or as ingredients.

These products are manufactured, tested, and released in an ISO 9001:2015 certified facility following cGMP practices.