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- Assay duration:Multiple steps
- Assay Type:Competitive
- Conjugate ELISA:Biotin
- Format:Pre-coated
- Host:Rabbit
- Primary antibody reactivity:Multiple
- Target protein:MDA
- Size:1 Kit
- Sample Type:Serum, Plasma and other biological fluids
- Cross Reactivity:No significant cross-reactivity or interference between High Sensitive Malondialdehyde (MDA) and analogues was observed
- Detection Method:Colorimetric
- Time to Results:3 h
- Shelf Life:12 Months
- Detection Range:12.35 - 1000 ng/ml
- Storage Temperature:4 °C for one month (frequent use), −20 °C for one year
- Sample Volume:50 µl
- Sensitivity:4.94 ng/ml
- Regulatory Status:RUO
- Cat. No.:MSPP-HEA597GE
- No. of tests:96 wells
This assay has high sensitivity and excellent specificity for detecting General species MDA (Malondialdehyde). The assay range is from 12.35 to 1,000 ng/ml (Competitive kit) with a sensitivity of 4.94 ng/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.
- High sensitivity and specificity
- Perfect reproducibility and consistency across batches
- Quality control with three-level inspections
- Wide range of targets/species available
- Intra-Assay: CV <10%, Inter-Assay: CV <12%
Malondialdehyde, MDA is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. MDA-modified proteins may show altered physico-chemical behavior and antigenicity. Malondialdehyde is a highly reactive compound that is not typically observed in pure form. In the laboratory it can be generated in situ by hydrolysis of 1,1,3,3-tetramethoxypropane, which is commercially available. It is easily deprotonated to give the sodium salt of the enolate (m.p. 245 °C). Malondialdehyde reacts with deoxyadenosine and deoxyguanosine in DNA, forming DNA adducts, primarily M1G, which is mutagenic. The guanidine group of arginine residues condense with MDA to give 2-aminopyrimidines.