- Antibody Type:Primary
- Antigen Name:Mitogen Activated Protein Kinase Kinase Kinase 6
- Antigen Symbol:MAP3K6
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Rat
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:313022
- Antigen Synonyms:ASK2|Apoptosis Signal Regulating Kinase 2|MAPKKK6|MEKK6
- Amino Acid Number:649 - 907
- UniProtKB:D3ZFL3
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:33 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant MAP3K6(Thr649~Leu907)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAD558RA1
- Packaging:Vial
Polyclonal antibody to Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6), derived from recombinant MAP3K6(Thr649~Leu907), is reactive with Rat.
- High specificity, affinity and purity
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MAP3K6 is a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. MAP3K6 and MAP3K5 share 45% amino acid sequence identity, their catalytic domains share 82% identity. The authors confirmed the interaction of MAP3K6 with MAP3K5 in vivo using coimmunoprecipitation. Recombinant MAP3K6 weakly activated the JNK but not the ERK or p38 kinase pathways.
Type: Primary
Antigen: MAP3K6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat