Specifications
- Antibody Type:Primary
- Antigen Name:Amiloride Binding Protein 1
- Antigen Symbol:ABP1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Antigen Synonyms:Amine oxidase copper domain-containing protein 1|DAO|Kidney amine oxidase|Histaminase|AOC1|Amiloride-sensitive amine oxidase|KAO|Diamine Oxidase
- Amino Acid Number:292 - 460
- UniProtKB:Q8JZQ5
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:21 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.85 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant ABP1(His292~Asn460)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA656MU1
- Packaging:Vial
Specifications
About this item
Polyclonal antibody to Amiloride Binding Protein 1 (ABP1), derived from recombinant ABP1(His292~Asn460), is reactive with Mouse/Rat.
- High specificity, affinity and purity
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On the basis of its primary structure, the amiloride-binding protein (EC 1.4.3.6) is 713 amino acids long, with a 19-amino acid signal peptide. Expressed in cultured cells, the mRNA yields a glycoprotein that binds amiloride and amiloride analogs with affinities similar to the amiloride receptor associated with the apical Na+ channel in pig kidney membranes and is immunoprecipitated with monoclonal antibodies raised against pig kidney amiloride-binding protein. Barbry et al. (1990) pointed out that amiloride-sensitive Na+ channels are also present in airway epithelia, where they play an important role in fluid secretion. Amiloride inhibits the excessive absorption of Na+ and liquid that takes place in airway epithelia of patients with cystic fibrosis, and amiloride aerosol therapy has been tried for the treatment of lung disease in CF.
Type: Primary
Antigen: ABP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat