Specifications
- Antibody Type:Primary
- Antigen Name:Poly ADP Ribose Polymerase
- Antigen Symbol:PARP
- Clonality:Monoclonal
- Clone:C2
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG1 kappa
- Reactivity:Human
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:142
- Antigen Synonyms:PARP1|PPOL|ADPRT1|pADPRT-1|NAD(+) ADP-ribosyltransferase 1|ADP-ribosyltransferase diphtheria toxin-like 1|ADPRT
- Amino Acid Number:788 - 1014
- UniProtKB:P09874
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:32 kDa
- Storage Temperature:Store at 2...8 °C for frequent use,−20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:1 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:recombinant PARP (Asp788~Trp1014)
- Purification:Protein A + Protein G affinity chromatography
- Cat. No.:MSPP-MA279HU21
- Packaging:Vial
Specifications
About this item
Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP), derived from recombinant PARP (Asp788~Trp1014), is reactive with Human.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death. RP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitroand is one of the main cleavage targets of caspase-3in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP1 is a chromatin-associated enzyme, poly-ADP ribose polymerase-1, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks.
Type: Primary
Antigen: PARP
Clonality: Monoclonal
Clone: C2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human