Specifications
- Antibody Type:Primary
- Antigen Name:Single Ig IL1 Related Receptor
- Antigen Symbol:SIGIRR
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Pig,Human
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:59307
- Antigen Synonyms:Single Ig IL-1R-related molecule|Toll/interleukin-1 receptor 8|TIR8|Single immunoglobulin domain-containing IL1R-related protein
- Amino Acid Number:1 - 118
- UniProtKB:Q6IA17
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:14 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant SIGIRR (Met1~His118)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAM229HU1
- Packaging:Vial
Specifications
About this item
Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR), derived from recombinant SIGIRR (Met1~His118), is reactive with Human/Pig.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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The deduced 410-amino acid human protein, which is 82% identical to the mouse sequence and 23% identical to IL1R, has no signal peptide and contains a short 118-amino acid single immunoglobulin (Ig) extracellular domain with 4 potential N-glycosylation sites; a transmembrane region; and a 268-amino acid cytoplasmic tail with 4 IL1R-like signaling motifs. However, 2 changes in the regions conserved with IL1R (ser447 in IL1R replaced by cys222 in motif 3 of SIGIRR, and tyr536 in IL1R replaced by leu305 in motif 4 of SIGIRR) are predicted to abrogate signaling capabilities. Northern blot analysis revealed wide but differential expression of predominant 2.4- and 1.5-kb transcripts and minor 4.4- and 0.9-kb transcripts in all tissues tested.
Type: Primary
Antigen: SIGIRR
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human;Pig