Specifications
- Antibody Type:Primary
- Antigen Name:Interleukin 18
- Antigen Symbol:IL18
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Chicken
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Antigen Synonyms:IL-1g|Interleukin-1 Gamma|Interleukin-1 Family Member 4|Interferon-Gamma-Inducing Factor|Iboctadekin|IL1-F4|IL1F4|IGIF
- Amino Acid Number:1 - 196
- UniProtKB:Q8QFQ8
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:27 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:1 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant IL18 (Met1~Leu196)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA064GA1
- Packaging:Vial
Specifications
About this item
Polyclonal Antibody to Interleukin 18 (IL18), derived from recombinant IL18 (Met1~Leu196), is reactive with Chicken.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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IL-18 is a 18 kDa novel cytokine which is identified as a costimulatory factor for production of interferon-γ (IFN- γ) in response to toxic shock. It shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 ß converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It has been reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. Apart from its physiological role, IL-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders.
Type: Primary
Antigen: IL18
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Chicken