Specifications
- Antibody Type:Primary
- Antigen Name:Gremlin 1
- Antigen Symbol:GREM1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Chicken,Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:395826
- Antigen Synonyms:CKTSF1B1|DRM|DAND2|Increased in high glucose protein 2|PIG2|IHG-2|Cysteine knot superfamily 1, BMP antagonist 1|Cell proliferation-inducing gene 2 protein
- Amino Acid Number:27 - 184
- UniProtKB:O73755
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:27 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant GREM1 (Arg27~Asp184)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAC128GA1
- Packaging:Vial
Specifications
About this item
Polyclonal Antibody to Gremlin 1 (GREM1), derived from recombinant GREM1 (Arg27~Asp184), is reactive with Chicken/Mouse/Rat.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway. Grem 1 inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development., Grem 1 regulation of BMP-4 in mice embryos is essential in kidney and lung branching morphogenesis. Data from microarrays of cancer and non-cancer tissues suggest that grem1 and other BMP antagonists are important in the survival of cancer stroma survival and proliferation in some cancers. Grem 1 expression is found in many cancers and is thought to play important roles in uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma carcinomas.
Type: Primary
Antigen: GREM1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Chicken;Mouse;Rat