- Antibody Type:Primary
- Antigen Name:N-Terminal Pro-Atrial Natriuretic Peptide
- Antigen Symbol:NT-ProANP
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:4878
- Antigen Synonyms:NT-Pro-ANP|N-ANP
- Amino Acid Number:25 - 123
- UniProtKB:P01160
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:41 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, –20 ℃ for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C.
- Immunogen:Recombinant NT-ProANP (Ala25~Arg123)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA484HU1
- Packaging:Vial
Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP), derived from recombinant NT-ProANP (Ala25~Arg123), is reactive with Human/Mouse/Rat.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
- All in stock and fast global delivery
- 100% Quality and service satisfaction guarantee
ANP is a hormone important in maintaining body fluid and sodium homeostasis. In cardiomyocytes, human ANP is synthesized as a 151-amino acid prepropeptide. After the signal peptide is removed by the signal peptidase, pro-ANP is stored in the dense granules of the cell. On stimulation, pro-ANP is released from the dense granules and activated on the cell surface by proteolytic cleavage at residue arginine 98, generating an NH2-terminal propeptide and a 26-amino acid COOH-terminal peptide that is biologically active. Plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes. Both N-ANP and N-BNP identifies a greater number of patients at risk of death or heart failure than either peptide alone.
Type: Primary
Antigen: NT-ProANP
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat