- Antibody Type:Primary
- Antigen Name:Prothrombin Fragment 1+2
- Antigen Symbol:F1+2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Pig,Human,Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:2147
- Amino Acid Number:44 - 327
- UniProtKB:P00734
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:50 and 70 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant F1+2(Ala44~Arg327)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA710HU1
- Packaging:Vial
Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2), derived from recombinant F1+2(Ala44~Arg327), is reactive with Human/Mouse/Rat/Pig.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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Prothrombin is a carbohydrate-protein compound in plasma essential to coagulation. In response to bleeding, a complex series of clotting-factor interactions leads to its conversion by thromboplastin to thrombin, which transforms fibrinogen in plasma into fibrin. Fibrin and platelets combine to form a clot. Prothrombin and prothrombin fragment F1+2 (F1+2) were demonstrated in the tumor stroma on cancer cells and on small blood vessels in areas of neoangiogenesis at the host-tumor interface. F1+2 is an indicator of local activation of blood coagulation in cancer tissue. Thrombin itself is impossible to quantitate and so the use of surrogate markers is necessary. The measurement of F1+2 would be an excellent marker of thrombin generation. This is helped by the fact that F1+2 is not generated in vivo by any other mechanism. Fragment 1+2 has a half life of about 1 hour and is cleared from the bloodstream by the liver.
Type: Primary
Antigen: F1+2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human;Mouse;Rat;Pig