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Specifications
- Antigen Name:CD3
- Clonality:Monoclonal
- Clone:17A2
- Conjugation:APC (Allophycocyanin)
- Host:Rat
- Isotype:IgG2b kappa
- Reactivity:Mouse
- Size:100 µg
- Environmentally Preferable:
- Gene ID:12501
- Cat. No.:MSPP-100-1607
Specifications
About this item
Rat monoclonal antibody against mouse CD3, APC-conjugated.
- T cells
This monoclonal antibody (clone 17A2) reacts with the mouse cluster of differentiation 3 (CD3) complex, which consists of epsilon, gamma, delta, and zeta polypeptide chains. CD3 is a member of the immunoglobulin superfamily and is primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 protein chains assemble with chains of T cell receptor (TCR) and together they form the TCR-CD3 complex. Use this recombinant monoclonal antibody in applications requiring detection of CD3, such as flow cytometry (FC) and the unconjugated antibody in Immunoprecipitation (IP) and FC. TCR-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T cell development and function, and it represents one of the most complex transmembrane receptors. Blocking studies using a CD3E-targeting antibody suggests that the 17A2 clone of CD3 antibody recognizes an epitope on the epsilon chain of the CD3 complex. The 17A2 antibody clone is widely used as a phenotypic marker for mouse T cells. In addition, as the CD3E chain within the TCR-CD3 complex contains intracellular signaling domains, binding of the 17A2 antibody clone to CD3 can induce cell activation.
Type:
Antigen: CD3
Clonality: Monoclonal
Clone: 17A2
Conjugation: APC
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Mouse