Anti-IL-4 Rat Monoclonal Antibody [clone: MP4-25D2]

Catalog # MSPP-100-1454

Supplier: STEMCELL Technologies

Catalog # MSPP-100-1454

Supplier: STEMCELL Technologies

Supplier Number: 100-1454

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Specifications

Antigen Name:
IL-4
Clonality:
Monoclonal
Clone:
MP4-25D2
Host:
Rat
Isotype:
IgG1 kappa
Reactivity:
Human
Size:
100 µg
Environmentally Preferable:
Gene ID:
3565
Cat. No.:
MSPP-100-1454

Specifications

About this item

Rat monoclonal antibody against human IL-4, unconjugated.

T cells CD4

This rat monoclonal antibody (clone MP4-25D2) reacts with human interleukin 4 (IL-4). IL-4 is an ~15 kDa protein primarily composed of a four-helix bundle (Powers et al.) and is produced by a host of immune cells including T helper 2 (Th2) cells, basophils, eosinophils, and mast cells (Gadani et al.). It exhibits high affinity for the IL-4 receptor alpha (IL-4Rα) chain, which dimerizes with either the common gamma chain (γc) or IL-13 receptor alpha 1 (IL-13Rα1), leading to activation of downstream JAK-STAT signaling (Heller at al.). IL-4 is involved in the differentiation of CD4+ T lymphocytes into Th2 cells (Silva-Filho et al.), class switching of B cells to IgE (Geha et al.), and activation of M2 macrophages with IL-13 via an alternative pathway (Gordon et al.).

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type: Anti-IL-4 Rat Monoclonal Antibody [clone: MP4-25D2]
Antigen: IL-4
Clonality: Monoclonal
Clone: MP4-25D2
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1 kappa
Reactivity: Human