Anti-CD150 (SLAM) Rat Monoclonal Antibody [clone: TC15-12F12.2]

Supplier: STEMCELL Technologies

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Supplier: STEMCELL Technologies

About this item

Rat monoclonal IgG2a antibody against mouse CD150 (SLAM), unconjugated.

Hematopoietic stem
Progenitor cells

The TC15-12F12.2 antibody reacts with CD150 (signaling lymphocyte activation molecule or SLAM), an ~75 kDa type I transmembrane glycoprotein that plays multiple roles in the immune response by serving as a cell adhesion molecule and/or coreceptor. It is differentially expressed by T cells, immature thymocytes, B cells, dendritic cells, macrophages, and endothelial cells. The expression pattern differs according to cell type and activation status. Expression is rapidly induced upon activation of T cells, B cells and dendritic cells, with synthesis by T cells being maintained on Th1 but not Th2 clones. CD150-mediated co-stimulation of TCR-activated T cells enhances the production of IFN-γ by Th1 cells, a response that can be augmented by binding of the TC15-12F12.2 antibody. CD150 is thought to mediate signal transduction by associating with the intracellular protein tyrosine phosphatase, SHP-2. CD150 also has functions in hematopoietic cell development and is a useful marker for detection of multipotent hematopoietic stem cells (in concert with other markers such as CD48 and CD41). CD150 is not expressed on non-multipotent hematopoietic progenitor cells.

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Type: Anti-CD150 (SLAM) Rat Monoclonal Antibody [clone: TC15-12F12.2]
Antigen: CD150 (SLAM)
Clonality: Monoclonal
Clone: TC15-12F12.2
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a lambda
Reactivity: Mouse

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