To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.
Specifications
- Protein/Peptide Type:Recombinant
- Source:
- Species:Human
- Size:1 ml
- Environmentally Preferable:
- Protein Synonyms:Cartilage-inducing factor|Differentiation inhibiting factor|TGF-beta-1|TGF-ꞵ1,Transforming growth factor beta 1
- Protein/Peptide Name:TGF-beta 1 (Cell Culture Ready)
- Purity:≥95% by SDS-PAGE
- Cat. No.:MSPP-100-0856
Specifications
About this item
Conveniently and consistently add transforming growth factor beta 1 (TGF-ꞵ1) to your cultures with this cell culture-ready formulation. This human recombinant TGF-ꞵ1 is precisely reconstituted to 0.1 mg/ml in 100 mM acetic acid and requires no additional preparation, improving reproducibility. Endotoxin levels are verified, using the LAL method to ensure consistency for use across multiple applications. A member of the TGF-β superfamily, TGF-β1 regulates diverse cellular phenotypes. TGF-β1 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins.
TGF-β1 has been used for:
hPSC culture maintenance:
Use TGF-β1 together with basic fibroblast growth factor (bFGF) to support the culture of undifferentiated human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (Amit et al. Biol Reprod, 2004).
Exogenus cell signaling:
Regulate a variety of functions, including cell proliferation, differentiation, and metabolism (Massagué Nat Rev Mol Cell Biol, 2000; McDowell et al. Curr Biol, 1997).
Immune cell Homeostatis:
Modulate B cell responses and mediate immunosuppressive effects on T cells and neutrophils (Letterio and Roberts Annu Rev Immunol, 1998).