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Detergent, Millipore Calbiochem® LPD-12, Merck
Detergent, Millipore Calbiochem® LPD-12, Merck
Catalog # 80601-900
Supplier:  MilliporeSigma
Detergent, Millipore Calbiochem® LPD-12, Merck
Catalog # 80601-900
Supplier:  MilliporeSigma
Supplier Number:  437600-1MG
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Specifications

  • Description:
    Millipore LPD-12
  • Size:
    1 mg
  • Environmentally Preferable:
  • Storage Temperature:
    –20 °C
  • Cat. No.:
    80601-900
  • Packaging:
    Plastic ampoule
  • Supplier no.:
    437600-1MG

Specifications

About this item

A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM; micelle MW ~ 23,100; aggregation number ~ 8.1; partial specific volume ~ 0.77 cm3/g). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 µM and [protein] ~ 22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.

A water soluble, amphiphilic α-helical, non-denaturing lipopeptide detergent (LPD) that forms small micelles (CMC <1 µM; micelle MW ~23,100; aggregation number ~8.1; partial specific volume ~0.77 cm3/g) and effectively mimics lipid bilayers. Shown to solubilize as well as stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~250 µM and [protein] ~22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.

Sequence: Ac-Ala-Orn(dodecanoyl)-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Tyr-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Ala-Orn(dodecanoyl)-Ala-NH₂

Supplied as a trifluoroacetate salt.

Following reconstitution, aliquot and freeze (–20°C). Stock solutions are stable for up to 3 months at –20°C.

Packaging: Packaged under inert gas
Caution: Toxicity: Irritant (B)