Pierce™ In-Solution Tryptic Digestion and Guanidination Kit contains proteomics grade trypsin, buffers and reagents to alkylate and digest proteins and then guanidinate the peptide fragments for mass spectrometry.

• Optimized trypsin digestion producing complete digests of protein ranging from 0.025 to 10 µg
• Optimized guanidination where reaction produces little or no N-terminal modification
• Protein can be digested and guanidinated all in a day

Accurate identification of proteins and analysis of post-translational modifications by mass spectrometry require accurate and complete protein digestion and peptide modification.