Obtain high-quality analytical results from mRNA digestions using Thermo Scientific™ SMART Digest™ RNase Kits.

• Fast and simple mRNA digestion
• High reproducibility
• High sensitivity
• High levels of data quality compatible with automation
• A simple process and control of digestion time ensure required fragment length for comprehensive mRNA sequencing by HRAM-MS
• Easily automate the entire protocol for high-throughput processing
• Single nuclease digestion allows full characterization of mRNA
• Increased reproducibility over existing protocols
• Higher data confidence
• No nuclease contamination of the analytical column

A significant advance in sample preparation for oligonucleotide mapping and quantitation.

These RNase kits use optimized, heat stable enzymes on magnetic beads, allowing for control of partial digestion to produce required fragments of ideal length for sequencing by HRAM-MS.

RNase kits are available with with two endoribonuclease enzyme specificities:
RNase T1 degrades single-stranded RNA at G residues
RNase A degrades single-stranded RNA at C and U residues