Specifications
- Antibody Type:Primary
- Antigen Name:EAP30
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Flow Cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG (H, L)
- Reactivity:Rat
- Size:100 µl
- Gene ID:11267
- Storage Buffer:0.01 M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol
- Molecular Weight:29
- Storage Temperature:Shipped at 4 ℃. Store at −20 °C for one year. Avoid repeated freeze/thaw cycles.
- Concentration:1 µg/µl
- Purification:Purified by protein A
- Cat. No.:77440-720
- Packaging:Vial
Specifications
About this item
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Type: Primary
Antigen: EAP30
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG (H, L)
Reactivity: Rat