Specifications
- Antibody Type:Primary
- Antigen Name:p150 CAF1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µl
- Epitope:355-450/956
- Form:Liquid
- Gene ID:10036
- Antigen Synonyms:NURF150|CAF1 subunit A|CAF1P150|CAF|CAF1P155|CHAF1A|CAF I 150 kDa subunit|CAF 1 150 kDa subunit|CAF 1 subunit A|CAF-1 p150|CAF-1 subunit A|hp150|Chromatin Assembly Factor I|CAF-I p150|CAF1 p150 Subunit|CAF1B|CAF-I 150 kDa subunit|Chromatin assembly factor I p150 subunit|DCAF1|CAF 1|CAF1 150 kDa subunit|Nucleosome Remodeling Factor 150kDa Subunit|Chromatin assembly factor I 150 kDa|Chromatin Assembly Factor 1 Subunit A p150|CAF1A|P150|CAF Ip150|CAF1|CAF I p150|Chromatin assembly factor 1 subunit A|CAF1A_HUMAN
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- Storage Temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human p150 CAF1
- Purification:Purified by Protein A
- Cat. No.:76107-678
- Packaging:Vial
Specifications
About this item
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
Type: Primary
Antigen: p150 CAF1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 355-450/956
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat