Specifications
- Antibody Type:Primary
- Antigen Name:CD46/MCP
- Clonality:Polyclonal
- Conjugation:Cy3®
- Flow Cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µl
- Epitope:251-355/355
- Form:Liquid
- Gene ID:4179
- Antigen Synonyms:Membrane cofactor protein|Trophoblast leukocyte common antigen|CD46|MIC10|MCP|TRA2.10|AHUS2|TLX
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7,4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Molecular Weight:43 kDa
- Storage Temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze–thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from Mouse CD46
- Tested Applications:ICC
- Purification:Purified by Protein A
- Cat. No.:10313-886
- Packaging:Vial
Specifications
About this item
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Type: Primary
Antigen: CD46/MCP
Clonality: Polyclonal
Clone:
Conjugation: Cy3
Public Immunogen Range: 251-355/355
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse