Specifications
- Antibody Type:Primary
- Antigen Name:PABP Methyl Arg455/460
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Other,Rat,Mouse
- Western Blot:Yes
- Size:100 µl
- Form:Liquid
- Gene ID:26986
- Antigen Synonyms:Polyadenylate-binding protein 1|PABP|Poly(A)-binding protein 1|PABPC2|PABP1|PAB1|PABPC1|PABP-1|PABPL1
- Modification:Methylation (Methyl Arg455/460)
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Molecular Weight:75 kDa
- Storage Temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic metylpeptide derived from human PABP around metylation site of Arg455/Arg460
- Tested Applications:ICC
- Purification:Purified by Protein A
- Cat. No.:76085-136
- Packaging:Vial
Specifications
About this item
Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.
Type: Primary
Antigen: PABP Methyl Arg455/460
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse; Rat; Others