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- Antibody Type:Primary
- Antigen Name:Osteoblast Specific Factor 2
- Antigen Symbol:OSF-2
- Clonality:Polyclonal
- Clone:Polyclonal
- Conjugation:Unconjugated
- Host:Sheep
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:0.1 mg
- Form:The antibody is lyophilized in 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE.
- Antigen Synonyms:POSTN|OSF-2|Osteoblast Specific Factor 2 (Pleiotrophin, PTN, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding growth factor 8, HBGF-8|OSF-2, Heparin-binding neurite outgrowth-promoting factor 2, HBNF-2, Heparin-binding brain mitogen, HBBM )|PN|NCK|Periostin|Fasciclin-I like
- Storage Buffer:Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
- Shipping Temperature:At ambient temperature
- Purification:Immunoaffinity chromatography on a column with immobilized recombinant Human OSF-2.
- Cat. No.:101076-794
- Supplier no.:RD184045100
Quality control test, Indirect ELISA – to determine titer of the antibody , SDS PAGE – to determine purity of the antibody, and BCA - to determine quantity of the antibody.
Periostin is a disulfide linked 90 kDa, 811 amino acid protein originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta-1(TGFbeta1) and bone morphogenetic protein (BMP-2). OSF-2 has a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain and a C-terminal domain. The fourfold repeated domain of OSF-2 shows homology with the insect protein fasciclin Periostin mRNA is expressed in the developing mouse embryonic and fetal heart, and that it is localized to the endocardial cushions that ultimately divide the primitive heart tube into a four-chambered heart.
Storage temperature: The lyophilized antibody remains stable and fully active until the expiry date when stored at –20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at –80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time; it does not show decline in activity after one week at 4 °C.