Versatile HIC column for native mode CQA characterization of mAbs, ADCs, and other proteins.

• Optimized selectivity – Ideal for mAb oxidation and ADC DAR ratios
• Single chemistry – Reduces the need for multiple-column screening for different CQAs
• Enhanced robustness – Improved column lifetime for ultimate confidence in your data
• Proven performance – Every batch of media is tested with NIST mAb
• High quality – Each column is individually tested to ensure packing efficiency
• Greater productivity – Shorter columns reduce analysis time while maintaining separation performance

Agilent AdvanceBio HIC columns deliver robust and reproducible high-resolution separations of native proteins at the intact level. Built using the capabilities of ZORBAX fully porous particles and proprietary bonding technology, AdvanceBio HIC columns provide new levels of hydrophobicity and selectivity to address particularly challenging molecules such as monoclonal antibodies (mAbs), antibody drug conjugates (ADCs), and other recombinant proteins. Together with the Agilent 1260 Infinity II bio-inert LC system, AdvanceBio HIC columns provide uncompromised performance and data consistency during characterization and validation.