Rat Recombinant ALK-1/ACVRL1 Protein (His & Fc Tag) (from HEK293 Cells)
103621-342
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- Conjugation:Unconjugated
- Protein Function:Immunotherapy
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Rat
- Size:200 µg
- Storage Conditions:–20…–80 °C
- Endotoxin Content:<1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity:Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953.
The ED50 for this effect is typically 40-200 ng/ml in the presence of 2 ng/ml of recombinant human BMP9. - Gene ID:NP_071886.1
- Reconstitution Instructions:A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
- Carrier-Free:Y
- Animal-Free:Y
- Protein Synonyms:HHT2|SKR3|ALK-1|TSR-I|ALK1|ORW2|ACVRLK1|HHT
- Protein/Peptide Name:ACVRL1
- Purity:>90% as determined by SDS-PAGE
- Molecular Weight:The secreted recombinant rat ACVRL1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 343 amino acids with a predicted molecular mass of 38.7 kDa. As a result of glycosylation, it migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing conditions.
- Sequence:Met1-Ala118
- Shipping Temperature:Ambient
- Cat. No.:103621-342
A synthetic DNA sequence encoding the rat ACVRL1 (NP_071886.1) extracellular domain (Met 1-Ala 118) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.