Rat Recombinant gp130/IL6ST/CD130 Protein (His & Fc Tag) (from HEK293 Cells)
Catalog # 103666-260
Supplier: Sino Biological
CAS Number:
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Specifications
- Conjugation:Unconjugated
- Protein Function:Immunotherapy
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Rat
- Size:100 µg
- Storage Conditions:–20…–80 °C
- Endotoxin Content:<1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity:Measured by its ability to inhibit the IL6 Rα enhancement of IL6 activity on M1 mouse myeloid leukemia cells (Saito, T. et al. 1991, J. Immunol. 147:168.). The ED50 for this effect is typically 0.015-0.075 μg/ml in the presence of 50 ng/ml recombinant human IL6sR and 100 ng/ml recombinant human IL6.
- Gene ID:NP_001008725.2
- Reconstitution Instructions:A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
- Carrier-Free:Y
- Animal-Free:Y
- Protein Synonyms:IL-6RB|GP130|CD130|CDW130
- Protein/Peptide Name:IL6ST
- Purity:>95% as determined by SDS-PAGE.
- Molecular Weight:The recombinant rat IL6ST/Fc is a disulfide-linked homodimer. The reduced monomer comprises 839 amino acids and predicts a molecular mass of 94.3 kDa. The apparent molecular mass of the rat IL6ST/Fc monomer is approximately 130 kDa in SDS-PAGE under reducing conditions due to glycosylation.
- Sequence:Met4-Glu618
- Shipping Temperature:Ambient
- Cat. No.:103666-260
Specifications
About this item
A DNA sequence encoding the rat IL6ST (NP_001008725.2) extracellular domain (Met 4-Glu 618) was fused with the C-terminal polyhistidine-tagged Fc region of mouse IgG1 at the C-terminus.