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Specifications
- Concentration:20% slurry in 10mM phosphate buffer + 0.02% sodium azide
- Description:High capacity Magne® streptavidin beads
- Size:3 ml
- Environmentally Preferable:
- Particle size:30 - 50 μm
- Binding Capacity:≥9 mg of goat anti-human biotinylated IgG/ml of settled resin or ≥1.8 mg of goat anti-human biotinylated IgG/ml of bead slurry
- Cat. No.:76201-362
Specifications
About this item
High Capacity Magne® Streptavidin Beads are magnetic affinity beads with high specificity and high capacity for binding biotinylated antibodies and proteins. The magnetic beads are composed of iron oxide encapsulated by macroporous cellulose, which results in beads that have low nonspecific binding.
- Ideal for use with complex biological samples
- Excellent magnetic properties for rapid and efficient capture
- Capture process can be automated for high throughput and scaled up to handle a variety of sample volumes
These beads are used for a variety of applications including pharmacokinetics studies of therapeutic antibodies. The high capacity of the beads enables enrichment of antibodies over a wide concentration range using a small amount of beads.
The affinity of streptavidin for biotin (Kd = 10⁻¹⁵ M) is one of the strongest, most stable interactions in biology; this interaction cannot be reversed under nondenaturing conditions. Hence, it is possible to perform extensive washing to remove nonspecifically bound protein and elute therapeutic antibodies without eluting the biotinylated component, thereby improving the detection limit of the antibody.