UCHL1 antibody recognizes Ubiquitin C-terminal hydrolase 1 (UCHL1) which is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
Therefore, UCHL1 monoclonal antibody is ideal for investigators involved in Neuroscience.

Anti-Ubiquitin Hydrolase antibody is suitable for use in ELISA and Western Blot and IF. Specific conditions for reactivity should be optimized by the end user. Expect a band of appproximately 24 kDa in size corresponding to the UCHL1 proteins in Western blot in the appropriate cell lysate or extract.

Type: Primary
Antigen: UCHL1
Clonality: Monoclonal
Clone: BH7
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: