Human Recombinant IRS1 (from Baculovirus (Sf9 Insect Cells))

About this item

IRS1 is the substrate for the insulin tyrosine kinase receptor and is found in a variety of insulin-responsive cells and tissues. IRS1 protein has no intrinsic enzymatic activity but acts as a docking protein, via the SH2 domains, for mediating the insulin downstream signaling events. IRS1 has been shown to associate with the 14-3-3 family of proteins and this could play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (1). IRS1 may be associated with colorectal cancer and diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling mediated by IRS1 may play a plausible role in the development of colorectal cancer (2). IRS1 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, AKT/PKB Pathway, Cancer, Cellular Stress, and ERK/MAPK Pathway research.

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Specifications

Protein/Peptide Type:
Recombinant
Source:
Baculovirus (Sf9 Insect cells)
Species:
Human
Storage Conditions:
Store product at –70 °C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Protein Synonyms:
Insulin Receptor Substrate 1|HIRS-1
Protein/Peptide Name:
IRS1
Purity:
>85%
Formulation:
Liquid (sterile filtered)
Shipping Temperature:
Dry Ice