Human Recombinant TrkA-Fc Chimera (from Mammalian Cells)

About this item

Human TrkA-Fc Chimera expressed in mammalian cells

TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. The TrkA-Fc chimera has N-linked and may have O-linked oligosaccharides.

Specifications

Conjugation:
Unconjugated
Protein Function:
Neurotrophin receptor
Protein/Peptide Type:
Recombinant
Source:
Mammalian cells
Species:
Human
Storage Conditions:
Lyophilized product should be stored at 2 to 8 °C. Following reconstitution, short-term storage at 4 °C is recommended and longer-term storage of aliquots at -18 to –20 °C. Repeated freeze thawing is not recommended.
Gene ID:
P04629 NTRK1_HUMAN;
Reconstitution Instructions:
Spin vial briefly before opening. Reconstitute in 200 uL sterile PBS, pH 7.4 to give a concentration of 0.5 mg/mL.
Protein Synonyms:
High affinity nerve growth factor receptor|Trk-A|Tropomyosin-related kinase receptor|TRK1 transforming tyrosine kinase protein|Neurotrophic tyrosine kinase receptor type 1|NTRK1|TRK|p140-TrkA
Protein/Peptide Name:
TrkA-Fc Chimera
Purity:
> 95% by SDS-PAGE
Formulation:
Lyophilised from PBS, pH 7.4 without preservatives.
Shipping Temperature:
ambient