Optimized Cas9 Nuclease S. Pyogenes is designed for genome editing in living cells or organisms and also for in vitro digestion.

• Increased genome editing efficiency using Cas9/RNP delivery
• Successful CRISPR/Cas9 genome editing can be performed through diverse approaches (plasmids, mRNA, nuclease, viral delivery)

The Cas 9 recombinant protein is delivered more rapidly than nucleic acid and is fully active once inside the cells without latency period (in contrast to transcription and translation machineries required for the nucleic acids). These features make nuclease protein delivery particularly well suited for precision genome engineering.

Efficient nucleic acid delivery represents a critical step for genome editing experiments.