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Specifications
- Antibody Type:Primary
- Antigen Name:CD7
- Antigen Symbol:CD7
- Clonality:Monoclonal
- Clone:T3-3A1
- Conjugation:RPE (R-Phycoerythrin)
- Host:Mouse
- ImmunoFluorescence:Yes
- Isotype:IgG1 kappa
- Reactivity:Human
- Size:250 μL
- Gene ID:Unigene ID: 186820
- Storage Buffer:PBS/0.1% BSA/0.05% azide
- Concentration:0.1 mg/mL
- Cat. No.:75918-854
- Supplier no.:BNCR0978-250
Specifications
About this item
This antibody recognizes a protein of 40 kDa, identified as CD7, a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Type: Primary
Antigen: CD7
Clonality: Monoclonal
Clone: Clone T3-3A1
Conjugation: R-PE
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human