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- Description:OPG ELISA Assay Kit
- Size:1 kit
- Cat. No.:102993-982
- Supplier no.:BI-20403
Human Osteoprotegerin ELISA detects human osteoprotegerin levels in serum or plasma samples.
- Dynamic Range: 0 to 20 pmol/l
- Sensitivity: LOD: (0 pmol/l + 3 SD): 0.07 pmol/l; LLOQ: 0.08 pmol/l
- Incubation: 5.5 hours
Osteoprotegerin (OPG) or Osteoclast inhibitory factor (OCIF) is a glycoprotein of the TNF receptor superfamily 11b (gene name TNFRSF11B). OPG is synthesized as a monomer of 380 amino acids and is assembled as a homodimer within the cell and then secreted mainly as a disulfide-linked homodimer into the extracellular compartment. OPG is produced by many different tissues and cell types including osteoblasts. OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification.